| Liver transplantation in a patient with encapsulating peritoneal sclerosis. | |
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MedLine Citation:
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PMID: 18663255 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Encapsulating peritoneal sclerosis (EPS) is a poorly understood condition in which excess fibrosis results in an encasement of the small bowel, which can clinically result in obstruction. The condition is thought to be related to the persistent expression of transforming growth factor beta on mesothelial cells causing proliferation of subserosal fibroblasts, massive production of extracellular matrix and loss of mesothelial cells. We report a patient with liver cirrhosis in whom the diagnosis of EPS was made. During laparotomy for liver transplantation the complete peritoneum was found to be thickened, consisting of white sheets; liver transplantation was deferred. Histological examination showed peritoneal sclerosing fibrosis. Immunosuppressive medication was started and a difficult but successful liver transplantation followed. If EPS is diagnosed during laparotomy for organ transplantation, adjusted immunosuppression is preferred as calcineurin inhibitors such as cyclosporin and tacrolimus may accelerate EPS while prednisone and some other drugs may stop progression. |
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Authors:
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W H de Vos Tot Nederveen Cappel; J Dubbeld; S M Willems; J Ringers; B van Hoek |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Netherlands journal of medicine Volume: 66 ISSN: 0300-2977 ISO Abbreviation: Neth J Med Publication Date: 2008 Jul-Aug |
Date Detail:
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Created Date: 2008-07-29 Completed Date: 2008-09-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0356133 Medline TA: Neth J Med Country: Netherlands |
Other Details:
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Languages: eng Pagination: 280-2 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology, Leiden University Medical Centre, the Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Biopsy Humans Liver Cirrhosis / complications, pathology, surgery* Liver Transplantation / methods* Male Peritoneal Diseases / complications*, pathology, surgery Peritoneum / pathology* Sclerosis / pathology, surgery |
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