| Liver toxicity induced by non-nucleoside reverse transcriptase inhibitors. | |
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MedLine Citation:
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PMID: 17255142 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Liver toxicity is one of the most relevant adverse effects of antiretroviral therapy. Within the non-nucleoside reverse transcriptase inhibitors (NNRTIs), efavirenz can be considered a safer drug for the liver than nevirapine. In fact, the frequency of severe increased liver enzymes in patients on efavirenz ranges from 1 to 8%, whereas in patients treated with nevirapine, it ranges from 4 to 18%. Likewise, nevirapine is more commonly associated than efavirenz with early acute hepatitis, which is produced by a hypersensitivity mechanism and has a defined risk profile that often makes it avoidable. Despite the fact that most cases of NNRTI-induced liver toxicity are asymptomatic, the rates of symptomatic events in patients treated with nevirapine are greater than in subjects on efavirenz. In any case, it is unusual for an NNRTI to be suspended due to liver toxicity. |
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Authors:
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Antonio Rivero; José A Mira; Juan A Pineda |
Publication Detail:
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Type: Journal Article; Review Date: 2007-01-25 |
Journal Detail:
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Title: The Journal of antimicrobial chemotherapy Volume: 59 ISSN: 0305-7453 ISO Abbreviation: J. Antimicrob. Chemother. Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-02-27 Completed Date: 2007-05-11 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 7513617 Medline TA: J Antimicrob Chemother Country: England |
Other Details:
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Languages: eng Pagination: 342-6 Citation Subset: IM |
Affiliation:
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Sección de Enfermedades Infecciosas, Hospital Universitario Reina Sofía, Cordoba, Spain. ariveror@saludalia.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alanine Transaminase
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blood Anti-HIV Agents / adverse effects* Aspartate Aminotransferases / blood Benzoxazines / adverse effects* Drug Hypersensitivity Drug-Induced Liver Injury / etiology Humans Liver / drug effects*, enzymology Nevirapine / adverse effects* Reverse Transcriptase Inhibitors / adverse effects* Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Anti-HIV Agents; 0/Benzoxazines; 0/Reverse Transcriptase Inhibitors; 129618-40-2/Nevirapine; 154635-17-3/efavirenz; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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