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Liver support systems: will they ever reach prime time?
MedLine Citation:
PMID:  23392862     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Liver support systems aim to provide temporary support of liver function while maintaining extra-hepatic function in patients with liver failure. Important advances have been achieved in the design of artificial and bio-artificial devices, but the current systems are far from meeting the ideal. Artificial devices provide detoxification through different dialysis procedures, whereas bio-artificial devices add synthetic functions by incorporating a cellular component into the system. Overall, liver support systems have consistently shown beneficial effects on the pathophysiology of liver failure, especially in acute-on-chronic liver failure. However, these beneficial effects have not been translated into an improvement of survival. Our review discusses the current evidence, paying special attention to the clinical aspects of (bio)-artificial liver support devices.
Authors:
Rafael Bañares; María-Vega Catalina; Javier Vaquero
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current gastroenterology reports     Volume:  15     ISSN:  1534-312X     ISO Abbreviation:  Curr Gastroenterol Rep     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888896     Medline TA:  Curr Gastroenterol Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  312     Citation Subset:  IM    
Affiliation:
Liver Unit, Facultad de Medicina, Universidad Complutense de Madrid, Hospital General Universitario Gregorio Marañón, IISGM, CIBEREHD, Madrid, Spain, rbanares@telefonica.net.
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