Document Detail

Liver stiffness is influenced by a standardized meal in patients with chronic hepatitis C virus at different stages of fibrotic evolution.
MedLine Citation:
PMID:  23447459     Owner:  NLM     Status:  MEDLINE    
Transient elastography (TE) is increasingly employed in clinical practice for the noninvasive detection of tissue fibrosis in patients with chronic liver disease (CLD), and particularly chronic hepatitis C virus (HCV)-related hepatitis. The present study was designed to provide a definitive characterization of the "confounding" increase in liver stiffness (LS) following a standardized meal in a consecutive population of 125 patients with chronic HCV infection at different stages of fibrotic evolution. LS values were obtained after overnight fasting and 15, 30, 45, 60, and 120 minutes following the onset of a standardized liquid meal (400 mL, 600 Kcal, 16.7% protein, 53.8% carbohydrates, 29.5% fat). An evident increase in LS values was observed 15 to 45 minutes after the onset of the meal with return to baseline premeal levels within 120 minutes in all patients. The peak postmeal delta increase in LS was progressively more marked with increasing stages of fibrosis (P < 0.001), becoming maximal in patients with cirrhosis. However, the probability of identifying the Metavir stage of fibrosis, the Child-Pugh class, or the presence/absence of esophageal varices with the postmeal delta increase in LS was inferior to that obtained with baseline LS values. Conclusion: The results of the present study provide definitive evidence of the confounding effect of a meal on the accuracy of LS measurements for the prediction of fibrosis stage in patients with chronic HCV hepatitis and suggest that a fasting period of 120 minutes should be observed before the performance of TE.
Umberto Arena; Monica Lupsor Platon; Cristina Stasi; Stefania Moscarella; Alì Assarat; Giorgio Bedogni; Valeria Piazzolla; Radu Badea; Giacomo Laffi; Fabio Marra; Alessandra Mangia; Massimo Pinzani
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Publication Detail:
Type:  Journal Article; Multicenter Study     Date:  2013-05-27
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  58     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-26     Completed Date:  2013-08-30     Revised Date:  2014-03-11    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  65-72     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 American Association for the Study of Liver Diseases.
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MeSH Terms
Confounding Factors (Epidemiology)
Elasticity Imaging Techniques / methods
Hepatitis C, Chronic / epidemiology,  pathology*
Liver / pathology*,  physiopathology
Liver Cirrhosis / diagnosis,  epidemiology
Middle Aged
Comment In:
Ann Hepatol. 2013 Sep-Oct;12(5):839-40   [PMID:  24018507 ]
Hepatology. 2014 Feb;59(2):734-5   [PMID:  23703696 ]
Hepatology. 2014 Jan;59(1):350-1   [PMID:  23703869 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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