Document Detail

Liver stem cells: when the going gets tough they get going.
MedLine Citation:
PMID:  9516869     Owner:  NLM     Status:  MEDLINE    
The ability of the liver to regenerate is widely acknowledged, and this is usually accomplished by the entry of normally proliferatively quiescent hepatocytes into the cell cycle. However, when hepatocyte regeneration is impaired, small bile ducts proliferate and invade into the adjacent hepatocyte parenchyma. In humans and experimental animals these ductal cells are referred to as oval cells, and their association with defective regeneration has led to the belief that they are the progeny of facultative stem cells. Oval cells are of great biological interest since they may represent a target population for hepatic carcinogens, and they may also be useful vehicles for ex vivo gene therapy for the correction of inborn errors of metabolism. The ability of oval cells to differentiate into hepatocytes has been demonstrated unequivocally. However, this process only occurs when the regenerative capacity of hepatocytes is overwhelmed, and thus, unlike the intestinal epithelium, the liver is not behaving as a classical continually renewing stem cell-fed lineage.
M R Alison; M Golding; C E Sarraf
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  International journal of experimental pathology     Volume:  78     ISSN:  0959-9673     ISO Abbreviation:  Int J Exp Pathol     Publication Date:  1997 Dec 
Date Detail:
Created Date:  1998-04-01     Completed Date:  1998-04-01     Revised Date:  2011-12-21    
Medline Journal Info:
Nlm Unique ID:  9014042     Medline TA:  Int J Exp Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  365-81     Citation Subset:  IM    
Histopathology Department, ICSM, London, UK.
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MeSH Terms
Bile Duct Neoplasms / pathology
Bile Ducts, Intrahepatic / pathology
Carcinoma, Hepatocellular / pathology
Cell Differentiation
Cell Division
Cholangiocarcinoma / pathology
Liver / cytology*,  pathology,  physiology*
Liver Diseases / pathology
Liver Neoplasms / pathology
Liver Regeneration*
Stem Cells / cytology*

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