| Liver sinusoidal blood containing natural killer-like cells. | |
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MedLine Citation:
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PMID: 2922574 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rat liver sinusoidal washout cells were examined. These cells, which are marginated in sinusoids, could be washed out by simple flushing of the vasculature with culture media without enzymes and under physiological portal pressure. They revealed, in comparison to peripheral blood mononuclear cells, high cytotoxic activity commonly attributed to the natural killer (NK) and natural cytotoxic (NC) cells, and were found to be anti-asialo-GM1-negative. Liver sinusoidal cytotoxic cell (LSCC) activity has been found to be associated with the large granular lymphocytes in low-density cells in OX8-positive as well as in OX8-negative populations. The mononuclear cells washed out from the liver microvasculature could be stimulated with NK-sensitive targets to release soluble factors which selectively lyse YAC-1 tumour cells and inhibit growth of normal haematopoietic granulocyte-macrophage colony-forming cells in vitro. The cytotoxic cell population in the liver turned out to be blood-borne in origin and not resident. Our findings suggest that liver sinusoidal cytotoxic cells represent an NK population with a predilection for marginating in the liver and may be important in eliminating tumour or virus infected cells passing through the liver from the circulation. The mechanism of their accumulation in liver sinusoids remains unclear. |
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Authors:
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B Lukomska; W L Olszewski; T Ryffa; A Ziolkowska; D Sadowska |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Scandinavian journal of immunology Volume: 29 ISSN: 0300-9475 ISO Abbreviation: Scand. J. Immunol. Publication Date: 1989 Feb |
Date Detail:
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Created Date: 1989-04-20 Completed Date: 1989-04-20 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0323767 Medline TA: Scand J Immunol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 239-46 Citation Subset: IM |
Affiliation:
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Department for Surgical Research and Transplantology, Medical Research Center, Polish Academy of Sciences, Warsaw. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carbohydrates / pharmacology Cell Separation Cytotoxicity, Immunologic Hematopoietic Stem Cells Killer Cells, Natural / immunology* Leukocytes, Mononuclear / immunology Liver / blood supply, immunology* Male Mice Mice, Inbred C57BL Rats Spleen / immunology |
| Chemical | |
Reg. No./Substance:
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0/Carbohydrates |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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