| Liver and serum antioxidant status after methanol intoxication in rats. | |
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MedLine Citation:
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PMID: 9241366 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Activities of superoxide dismutase (SOD), catalase, glutathione peroxidase (GSH-Px) and glutathione reductase (GSSG-R) and concentration of ascorbate, alpha-tocopherol, non-protein and protein-bound sulfhydryl compounds and thiobarbituric acid-reactive substances (TBA-rs) were measured in liver and serum of rats 6, 12 and 24 h and 2, 5 and 7 days after intoxication with 1.5 g or 3.0 g methanol/kg b.w. Liver GSH-Px and GSSG-R activities and SH-groups and ascorbate content were significantly diminished at 6 and 24 h, while TBA-rs were increased. Serum SOD, GSH-Px and GSSG-R activities and SH-groups concentration were reduced while TBA-rs were elevated. The changes were more intensive after application of the higher dose of methanol. It is concluded that methanol impairs the liver and blood serum antioxidant mechanisms in rats. |
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Authors:
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E Skrzydlewska; R Farbiszewski |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta biochimica Polonica Volume: 44 ISSN: 0001-527X ISO Abbreviation: Acta Biochim. Pol. Publication Date: 1997 |
Date Detail:
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Created Date: 1997-09-09 Completed Date: 1997-09-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 14520300R Medline TA: Acta Biochim Pol Country: POLAND |
Other Details:
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Languages: eng Pagination: 139-45 Citation Subset: IM |
Affiliation:
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Department of Instrumental Analysis, Medical Academy, Białystok, Poland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alcoholic Intoxication
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metabolism* Animals Antioxidants / metabolism* Liver / metabolism*, pathology Male Methanol / poisoning* Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 67-56-1/Methanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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