| Liver resection for hepatocellular carcinoma in a hepatitis B endemic area. | |
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MedLine Citation:
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PMID: 17610112 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver. Treatment options include liver resection, tumor ablation, and liver transplantation. METHODS: We report the results of all patients undergoing partial hepatectomy for HCC with curative intent from a center where all major treatment modalities were available. RESULTS: A series of 53 patients were identified, of whom 72% had underlying liver disease, mostly chronic hepatitis B infection. Altogether, 57% of patients underwent major resections, of whom 43% had histologically proven cirrhosis. Postoperative morbidity and mortality occurred in 41.5% and 7.5%, respectively. After a median follow-up of 34 months, the survival probabilities at 1, 3, and 5 years were 74.1%, 54.1%, and 42.6%, respectively. A total of 47% developed recurrent disease over the study period with a median disease-free survival of 13.8 months. The probabilities of recurrence at 1, 3, and 5 years were 35.2%, 49.4%, and 55.9%, respectively. Among those who developed recurrence, 76% died, with a median time to death from the time the recurrence was diagnosed of 7.8 months. There was a good association between the CLIP score and survival following liver resection. Multivariate analysis showed that only tumor recurrence and the presence of cirrhosis was a significant determinant of the risk of tumor-related death. CONCLUSION: These findings confirm that with careful patient selection liver resection for HCC can achieve good long-term patient survival and acceptable risks. |
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Authors:
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Adam St J R Bartlett; John L McCall; Jonathan B Koea; Andrew Holden; Mee-Ling Yeong; Nishanthi Gurusinghe; Ed Gane |
Publication Detail:
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Type: Journal Article Date: 2007-07-04 |
Journal Detail:
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Title: World journal of surgery Volume: 31 ISSN: 0364-2313 ISO Abbreviation: World J Surg Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-08-20 Completed Date: 2007-12-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7704052 Medline TA: World J Surg Country: United States |
Other Details:
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Languages: eng Pagination: 1775-81 Citation Subset: IM |
Affiliation:
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Department of Hepatobiliary and Transplant Surgery, New Zealand Liver Transplant Unit, Level 15, Support Building, Auckland City Hospital, Park Road, Grafton, Auckland, New Zealand. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Carcinoma, Hepatocellular / epidemiology, surgery*, virology Child Female Follow-Up Studies Hepatectomy* Hepatitis B, Chronic / complications* Humans Liver Neoplasms / epidemiology, surgery*, virology Male Middle Aged Multivariate Analysis Neoplasm Recurrence, Local* / surgery New Zealand / epidemiology Prospective Studies Risk Factors Survival Analysis Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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