Document Detail

Liver regeneration and recanalization time course following reversible portal vein embolization.
MedLine Citation:
PMID:  18387688     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: Permanent portal vein embolization (PVE) is a widely practised technique. The use of an absorbable material would be safer in clinical situations in which the embolized liver is not resected. We evaluated the efficiency of reversible PVE in terms of liver regeneration and analyzed the precise time course of portal recanalization. METHODS: Nine monkeys underwent PVE of the left and right anterior portal branches using powdered absorbable material. Repeated portograms were carried out until complete revascularization of the embolized liver. Hepatocyte proliferation rates were assessed by BrdU incorporation. Liver segment volumes were determined by CT scans performed before embolization, then 1 month and 1 year after embolization. RESULTS: Reversible PVE induced significant hepatocyte proliferation in the non-embolized segments (13.5+/-1.0%, 10.5+/-0.8% and 9.1+/-2.0% of cells on days 3, 5 and 7, respectively). One month after the embolization, the non-embolized liver volume had increased from 38.4+/-1.3% to 54.8+/-0.5% of total liver volume. Proximal and complete revascularization occurred 6-8 and 12-16 days, respectively. CONCLUSIONS: Reversible PVE efficiently induces liver regeneration. The use of absorbable material avoids long-term liver scarring. Such material may be suitable for several clinical indications, including cell transplantation.
Panagiotis Lainas; Lyes Boudechiche; Angel Osorio; Aurore Coulomb; Anne Weber; Danièle Pariente; Dominique Franco; Ibrahim Dagher
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-03-10
Journal Detail:
Title:  Journal of hepatology     Volume:  49     ISSN:  0168-8278     ISO Abbreviation:  J. Hepatol.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-11     Completed Date:  2008-12-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8503886     Medline TA:  J Hepatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  354-62     Citation Subset:  IM    
Inserm U804, University Paris-Sud, Kremlin-Bicêtre, France.
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MeSH Terms
Cell Proliferation
Disease Models, Animal
Embolization, Therapeutic / methods*
Gelatin Sponge, Absorbable / therapeutic use
Hypertrophy / chemically induced,  pathology
Liver / blood supply*,  pathology,  surgery
Liver Regeneration / physiology*
Macaca mulatta
Neovascularization, Physiologic / physiology
Portal Vein / physiopathology*
Time Factors
Comment In:
J Hepatol. 2008 Sep;49(3):313-5   [PMID:  18644648 ]

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