| Liver regeneration and recanalization time course following reversible portal vein embolization. | |
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MedLine Citation:
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PMID: 18387688 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: Permanent portal vein embolization (PVE) is a widely practised technique. The use of an absorbable material would be safer in clinical situations in which the embolized liver is not resected. We evaluated the efficiency of reversible PVE in terms of liver regeneration and analyzed the precise time course of portal recanalization. METHODS: Nine monkeys underwent PVE of the left and right anterior portal branches using powdered absorbable material. Repeated portograms were carried out until complete revascularization of the embolized liver. Hepatocyte proliferation rates were assessed by BrdU incorporation. Liver segment volumes were determined by CT scans performed before embolization, then 1 month and 1 year after embolization. RESULTS: Reversible PVE induced significant hepatocyte proliferation in the non-embolized segments (13.5+/-1.0%, 10.5+/-0.8% and 9.1+/-2.0% of cells on days 3, 5 and 7, respectively). One month after the embolization, the non-embolized liver volume had increased from 38.4+/-1.3% to 54.8+/-0.5% of total liver volume. Proximal and complete revascularization occurred 6-8 and 12-16 days, respectively. CONCLUSIONS: Reversible PVE efficiently induces liver regeneration. The use of absorbable material avoids long-term liver scarring. Such material may be suitable for several clinical indications, including cell transplantation. |
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Authors:
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Panagiotis Lainas; Lyes Boudechiche; Angel Osorio; Aurore Coulomb; Anne Weber; Danièle Pariente; Dominique Franco; Ibrahim Dagher |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-03-10 |
Journal Detail:
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Title: Journal of hepatology Volume: 49 ISSN: 0168-8278 ISO Abbreviation: J. Hepatol. Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-08-11 Completed Date: 2008-12-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8503886 Medline TA: J Hepatol Country: England |
Other Details:
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Languages: eng Pagination: 354-62 Citation Subset: IM |
Affiliation:
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Inserm U804, University Paris-Sud, Kremlin-Bicêtre, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biopsy Cell Proliferation Disease Models, Animal Embolization, Therapeutic / methods* Female Gelatin Sponge, Absorbable / therapeutic use Hypertrophy / chemically induced, pathology Liver / blood supply*, pathology, surgery Liver Regeneration / physiology* Macaca mulatta Neovascularization, Physiologic / physiology Portal Vein / physiopathology* Time Factors |
| Comments/Corrections | |
Comment In:
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J Hepatol. 2008 Sep;49(3):313-5
[PMID:
18644648
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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