Document Detail

Liver regeneration: alternative epithelial pathways.
MedLine Citation:
PMID:  19788929     Owner:  NLM     Status:  MEDLINE    
Loss of hepatic tissue triggers a regenerative response in the whole organ. Under typical normal conditions, all hepatic cells (epithelial: hepatocytes and biliary epithelial cells; non-epithelial: stellate cells, macrophages and endothelial cells) undergo one to three rounds of replication to establish the original number of cells and restore organ size. The review summarizes the literature of regenerative patterns in situations in which proliferation of either hepatocytes or biliary epithelial cells is inhibited. The evidence strongly suggests that under these circumstances, hepatocytes or biliary epithelial cells can function as facultative stem cells for each other and replenish the inhibited cellular compartment by a process of transdifferentiation, involving complex signaling pathways. These pathways are activated under experimental conditions in rodents and in fulminant hepatitis associated with liver failure in humans. Mechanistic analysis of these pathways has implications for liver biology and for potential therapeutic modalities in human liver disease.
George K Michalopoulos
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Publication Detail:
Type:  Journal Article; Review     Date:  2009-09-27
Journal Detail:
Title:  The international journal of biochemistry & cell biology     Volume:  43     ISSN:  1878-5875     ISO Abbreviation:  Int. J. Biochem. Cell Biol.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-17     Completed Date:  2011-06-08     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  9508482     Medline TA:  Int J Biochem Cell Biol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  173-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2009 Elsevier Ltd. All rights reserved.
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MeSH Terms
Autocrine Communication
Bile Ducts / cytology
Cell Proliferation
Cell Transdifferentiation
Epithelial Cells / cytology*
Hepatocytes / cytology
Intercellular Signaling Peptides and Proteins / metabolism
Liver / cytology*,  surgery
Liver Regeneration*
Signal Transduction
Stem Cells / cytology
Grant Support
R01 CA035373/CA/NCI NIH HHS; R01 CA035373-27/CA/NCI NIH HHS; R01 CA103958/CA/NCI NIH HHS; R01 CA103958-05/CA/NCI NIH HHS; UL1 RR024153/RR/NCRR NIH HHS; UL1 TR000005/TR/NCATS NIH HHS
Reg. No./Substance:
0/Intercellular Signaling Peptides and Proteins

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