| Liver position is a prenatal predictive factor of prosthetic repair in congenital diaphragmatic hernia. | |
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MedLine Citation:
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PMID: 18417990 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine whether any common maternal-fetal variable has prenatal predictive value of prosthetic repair in congenital diaphragmatic hernia. METHODS: This was a 5-year single-center retrospective review of fetal congenital diaphragmatic hernia referrals. Multiple prenatal variables were correlated with the need for a prosthetic repair. Statistical analyses were by Fisher's exact and Mann-Whitney U-tests, as appropriate (p < 0.05). RESULTS: Fetal liver position was a predictor of prosthetic repair. The presence or absence of liver herniation was correlated with prosthetic repair rates of 83.3 and 23.1%, respectively (p < 0.001). All patients with moderate/severe liver herniation required a prosthetic patch. CONCLUSION: Liver herniation has prenatal predictive value for the need for prosthetic repair in congenital diaphragmatic hernia. This finding should be valuable during prenatal counseling for clinical trials of engineered diaphragmatic repair. |
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Authors:
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Shaun M Kunisaki; Carol E Barnewolt; Judy A Estroff; Luanne P Nemes; Russell W Jennings; Jay M Wilson; Dario O Fauza |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2008-04-14 |
Journal Detail:
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Title: Fetal diagnosis and therapy Volume: 23 ISSN: 1421-9964 ISO Abbreviation: Fetal. Diagn. Ther. Publication Date: 2008 |
Date Detail:
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Created Date: 2008-04-17 Completed Date: 2008-06-04 Revised Date: 2010-09-21 |
Medline Journal Info:
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Nlm Unique ID: 9107463 Medline TA: Fetal Diagn Ther Country: Switzerland |
Other Details:
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Languages: eng Pagination: 258-62 Citation Subset: IM |
Copyright Information:
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(c) 2008 S. Karger AG, Basel. |
Affiliation:
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Department of Surgery, Children's Hospital Boston and Harvard Medical School, Boston, MA 02115, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biocompatible Materials Female Hernia, Diaphragmatic / congenital*, diagnosis, surgery* Humans Infant, Newborn Liver / pathology* Male Polytetrafluoroethylene Pregnancy Prenatal Diagnosis Prognosis Retrospective Studies Surgical Mesh Tissue Engineering |
| Grant Support | |
ID/Acronym/Agency:
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DK065406-02/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 9002-84-0/Polytetrafluoroethylene |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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