Document Detail

Liver position is a prenatal predictive factor of prosthetic repair in congenital diaphragmatic hernia.
MedLine Citation:
PMID:  18417990     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine whether any common maternal-fetal variable has prenatal predictive value of prosthetic repair in congenital diaphragmatic hernia. METHODS: This was a 5-year single-center retrospective review of fetal congenital diaphragmatic hernia referrals. Multiple prenatal variables were correlated with the need for a prosthetic repair. Statistical analyses were by Fisher's exact and Mann-Whitney U-tests, as appropriate (p < 0.05). RESULTS: Fetal liver position was a predictor of prosthetic repair. The presence or absence of liver herniation was correlated with prosthetic repair rates of 83.3 and 23.1%, respectively (p < 0.001). All patients with moderate/severe liver herniation required a prosthetic patch. CONCLUSION: Liver herniation has prenatal predictive value for the need for prosthetic repair in congenital diaphragmatic hernia. This finding should be valuable during prenatal counseling for clinical trials of engineered diaphragmatic repair.
Shaun M Kunisaki; Carol E Barnewolt; Judy A Estroff; Luanne P Nemes; Russell W Jennings; Jay M Wilson; Dario O Fauza
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-04-14
Journal Detail:
Title:  Fetal diagnosis and therapy     Volume:  23     ISSN:  1421-9964     ISO Abbreviation:  Fetal. Diagn. Ther.     Publication Date:  2008  
Date Detail:
Created Date:  2008-04-17     Completed Date:  2008-06-04     Revised Date:  2010-09-21    
Medline Journal Info:
Nlm Unique ID:  9107463     Medline TA:  Fetal Diagn Ther     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  258-62     Citation Subset:  IM    
Copyright Information:
(c) 2008 S. Karger AG, Basel.
Department of Surgery, Children's Hospital Boston and Harvard Medical School, Boston, MA 02115, USA.
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MeSH Terms
Biocompatible Materials
Hernia, Diaphragmatic / congenital*,  diagnosis,  surgery*
Infant, Newborn
Liver / pathology*
Prenatal Diagnosis
Retrospective Studies
Surgical Mesh
Tissue Engineering
Grant Support
Reg. No./Substance:
0/Biocompatible Materials; 9002-84-0/Polytetrafluoroethylene

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