Document Detail

Liver methylene fraction by dual- and triple-echo gradient-echo imaging at 3.0T: Correlation with proton MR spectroscopy and estimation of robustness after SPIO administration.
MedLine Citation:
PMID:  21182129     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To assess the systematic errors in liver methylene fraction (LMF) resulting from fat-fat interference effects with dual- and triple-echo gradient-recalled-echo Dual/Triple GRE) sequences and to test the robustness of these sequences after iron overloading.
MATERIALS AND METHODS: Forty type-2 diabetic patients underwent LMF measurement by 3.0T ¹H magnetic resonance spectroscopy (corrected for T1 and T2 decays) as the reference standard and liver fat fraction (%Fat) measurement by four Dual/Triple GRE sequences with 20° and 60° flip angle (α), corrected for T1 recovery. The same four sequences were repeated in eight patients after ferumoxide injection. Corrections for systematic errors were determined from the linear regressions (spectroscopy LMF values over Dual/Triple GRE %Fat values). Robustness was tested using Wilcoxon's signed-rank test.
RESULTS: Fat-fat interference effects produced a ∼10% relative systematic error and T2* decay produced a 1.9%-4.2% absolute systematic error in LMF. When comparing before and after ferumoxide, dual-echo imaging with α = 20° and α = 60°, even when corrected, showed absolute differences of 7.23% [2.81%-10.25%] (P = 0.0117) and 5.65% [1.89%-8.216.8%] (P = 0.0117), respectively; compared to only 1.17% [0.08%-2.83%] (P = 0.0251) and 1.15% [0.37%-2.73%] (P = 0.2626) with triple-echo imaging and α = 20° and α = 60°, respectively.
CONCLUSION: Triple-echo imaging with α = 60° corrected for both T1 recovery and fat-fat interference effects is robust after superparamagnetic iron oxide (SPIO) administration and can reliably quantify LMF.
Boris Guiu; Jean-Michel Petit; Romaric Loffroy; Serge Aho; Douraied Ben Salem; David Masson; Isabelle Robin; Bruno Vergès; Patrick Hillon; Jean-Pierre Cercueil; Denis Krausé
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of magnetic resonance imaging : JMRI     Volume:  33     ISSN:  1522-2586     ISO Abbreviation:  J Magn Reson Imaging     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-24     Completed Date:  2011-04-15     Revised Date:  2013-04-11    
Medline Journal Info:
Nlm Unique ID:  9105850     Medline TA:  J Magn Reson Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  119-27     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Wiley-Liss, Inc.
University of Burgundy, INSERM U866, Dijon, France.
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MeSH Terms
Adipose Tissue / metabolism*,  pathology
Biological Markers / metabolism
Carbon Compounds, Inorganic / metabolism*
Contrast Media / administration & dosage
Dextrans / diagnostic use,  pharmacokinetics*
Echo-Planar Imaging / methods
Fatty Liver / complications,  diagnosis,  metabolism
Iron Overload / complications,  diagnosis,  metabolism*
Liver / metabolism*,  pathology
Magnetic Resonance Spectroscopy / methods*
Magnetite Nanoparticles / diagnostic use
Middle Aged
Protons / diagnostic use
Reproducibility of Results
Sensitivity and Specificity
Statistics as Topic
Tissue Distribution
Reg. No./Substance:
0/Biological Markers; 0/Carbon Compounds, Inorganic; 0/Contrast Media; 0/Magnetite Nanoparticles; 0/Protons; 9004-54-0/Dextrans; G6N3J05W84/ferumoxides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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