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Liver-metastatic Potential of Colorectal Cancer Is Related to the Stromal Composition of the Tumour.
MedLine Citation:
PMID:  23225415     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
BACKGROUND: The tumour stroma is an important modulator of cancer cell behaviour. The aim of this study was to compare the stromal composition between primary colorectal cancer (CRC) and colorectal liver metastases (CLM).
MATERIALS AND METHODS: The stromal composition in matched tissue sections of CRC and subsequent CLM was analysed, and related to clinical parameters.
RESULTS: Differences in the expression pattern of type I collagen and type IV collagen in CRC was related to a higher risk of CLM. Two types of CLM the desmoplastic and pushing type were identified. The time between CRC and diagnosis of CLM was shorter (p=0.047) for desmoplastic CLM. The mortality rate was higher for pushing CLM due to frequent extrahepatic disseminated disease. A difference in the overall survival rate between patients with desmoplastic and those with pushing CLM was seen at follow-up of more than 60 months (p=0.046).
CONCLUSION: The liver-metastasizing potential is related to the stromal composition of primary CRC. There are distinct growth patterns in CLM with differences in stromal composition and clinical outcome.
Authors:
Hanna Nyström; Peter Naredi; Anette Berglund; Richard Palmqvist; Björn Tavelin; Malin Sund
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anticancer research     Volume:  32     ISSN:  1791-7530     ISO Abbreviation:  Anticancer Res.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  5183-91     Citation Subset:  IM    
Affiliation:
Department of Surgical and Perioperative Sciences, Surgery, Umeå University, 90185 Umeå, Sweden. malin.sund@surgery.umu.se.
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