Document Detail

Liver and kidney ultrastructural changes caused by acetylsalicylic acid treatment during pregnancy in rats.
MedLine Citation:
PMID:  12013090     Owner:  NLM     Status:  MEDLINE    
The worldwide use of acetylsalicylic acid (ASA) as an analgesic-antipyretic drug, including during pregnancy, prompted us to investigate its potentially deleterious effects in that condition. Pregnant rats were treated with ASA (1, 10 or 100 mg/kg once a day) from the first day up to term pregnancy. No histological changes were noticed in maternal and fetal livers or kidneys when examined under light microscopy, but some definite dose-dependent effects of ASA were observed on electron microscopy examination. In livers and kidneys of pregnant rats treated with the highest doses of ASA we observed cytoplasmic derangement, mitochondrial cristolysis and abnormally shaped rough endoplasmic reticulum. Similarly, in foetal livers and kidneys from this group we observed degenerative cytoplasmic vacuoles and ballooned mitochondria with cristae derangement and myelin figures. Our data point out the fact that both maternal and foetal tissues can be importantly affected by ASA at the ultrastructural level, without overt signs of toxicity.
S Espiridião; R M Oliveira-Filho; M J Simões; J A V Mamede; L Kulay
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental obstetrics & gynecology     Volume:  29     ISSN:  0390-6663     ISO Abbreviation:  Clin Exp Obstet Gynecol     Publication Date:  2002  
Date Detail:
Created Date:  2002-05-15     Completed Date:  2002-11-04     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7802110     Medline TA:  Clin Exp Obstet Gynecol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  37-9     Citation Subset:  IM    
Fundação ABC School of Medicine, Brazil.
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MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage*,  adverse effects
Aspirin / administration & dosage*,  adverse effects
Kidney / drug effects*,  embryology,  ultrastructure*
Liver / drug effects*,  embryology,  ultrastructure*
Rats, Wistar
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 50-78-2/Aspirin

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