| Liver iron status and associated haematological parameters in relation to fetal growth and pregnancy outcome in rapidly growing adolescent sheep carrying a singleton lamb derived by embryo transfer. | |
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MedLine Citation:
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PMID: 20883648 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Maternal and fetal liver iron concentrations and associated haematology parameters were determined in an adolescent sheep paradigm characterised by rapid maternal growth, premature delivery and feto-placental growth restriction. Singleton-bearing dams were offered a control or high dietary intake to induce normal or growth-restricted pregnancies, respectively. Pregnancies were terminated on Day 90 or 130 of gestation or progressed to term. Relative blood volume increased (P < 0.05) and liver iron concentration decreased (P < 0.003) from mid to late gestation in control, but not in high-intake dams. At 90 and 130 days gestation, liver iron concentrations were reduced (P < 0.001) in high-intake dams but fetal liver iron was independent of dam nutrition. High intakes leading to poor pregnancy outcome at term were characterised by increased maternal haematocrit, haemoglobin, total plasma protein, albumin (all P < 0.001) and serum iron (P < 0.05), and by reduced oestradiol 17β (P < 0.001) at Day 130. Thus, high dietary intakes that promote rapid maternal growth and adiposity are associated with early depletion of maternal liver iron stores and a relative failure of normal blood volume expansion, which may, in turn, underlie the reduction in uteroplacental blood flows and fetal nutrient delivery previously established for this paradigm. |
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Authors:
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Justin Luther; Raymond Aitken; John Milne; Harry McArdle; Lorraine Gambling; Lawrence Reynolds; Dale Redmer; Jacqueline Wallace |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Reproduction, fertility, and development Volume: 22 ISSN: 1031-3613 ISO Abbreviation: Reprod. Fertil. Dev. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-10-04 Completed Date: 2010-12-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8907465 Medline TA: Reprod Fertil Dev Country: Australia |
Other Details:
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Languages: eng Pagination: 1230-6 Citation Subset: IM |
Affiliation:
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University of Aberdeen Rowett Institute of Nutrition and Health, Aberdeen, AB21 9SB, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adiposity Animal Nutritional Physiological Phenomena Animals Biological Markers / blood Blood Proteins / metabolism Blood Volume Eating Estradiol / blood Female Fetal Development Fetal Growth Retardation / metabolism, physiopathology, veterinary* Gestational Age Hemoglobins / metabolism Iron / blood, metabolism* Liver / embryology, metabolism* Maternal Age Maternal Nutritional Physiological Phenomena Placental Circulation Pregnancy Pregnancy Outcome / veterinary* Premature Birth Reproductive Techniques, Assisted / veterinary* Sheep Single Embryo Transfer / veterinary* |
| Grant Support | |
ID/Acronym/Agency:
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HD045784/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Blood Proteins; 0/Hemoglobins; 50-28-2/Estradiol; 7439-89-6/Iron |
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