Document Detail

Liver iron status and associated haematological parameters in relation to fetal growth and pregnancy outcome in rapidly growing adolescent sheep carrying a singleton lamb derived by embryo transfer.
MedLine Citation:
PMID:  20883648     Owner:  NLM     Status:  MEDLINE    
Maternal and fetal liver iron concentrations and associated haematology parameters were determined in an adolescent sheep paradigm characterised by rapid maternal growth, premature delivery and feto-placental growth restriction. Singleton-bearing dams were offered a control or high dietary intake to induce normal or growth-restricted pregnancies, respectively. Pregnancies were terminated on Day 90 or 130 of gestation or progressed to term. Relative blood volume increased (P < 0.05) and liver iron concentration decreased (P < 0.003) from mid to late gestation in control, but not in high-intake dams. At 90 and 130 days gestation, liver iron concentrations were reduced (P < 0.001) in high-intake dams but fetal liver iron was independent of dam nutrition. High intakes leading to poor pregnancy outcome at term were characterised by increased maternal haematocrit, haemoglobin, total plasma protein, albumin (all P < 0.001) and serum iron (P < 0.05), and by reduced oestradiol 17β (P < 0.001) at Day 130. Thus, high dietary intakes that promote rapid maternal growth and adiposity are associated with early depletion of maternal liver iron stores and a relative failure of normal blood volume expansion, which may, in turn, underlie the reduction in uteroplacental blood flows and fetal nutrient delivery previously established for this paradigm.
Justin Luther; Raymond Aitken; John Milne; Harry McArdle; Lorraine Gambling; Lawrence Reynolds; Dale Redmer; Jacqueline Wallace
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Reproduction, fertility, and development     Volume:  22     ISSN:  1031-3613     ISO Abbreviation:  Reprod. Fertil. Dev.     Publication Date:  2010  
Date Detail:
Created Date:  2010-10-04     Completed Date:  2010-12-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8907465     Medline TA:  Reprod Fertil Dev     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  1230-6     Citation Subset:  IM    
University of Aberdeen Rowett Institute of Nutrition and Health, Aberdeen, AB21 9SB, UK.
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MeSH Terms
Animal Nutritional Physiological Phenomena
Biological Markers / blood
Blood Proteins / metabolism
Blood Volume
Estradiol / blood
Fetal Development
Fetal Growth Retardation / metabolism,  physiopathology,  veterinary*
Gestational Age
Hemoglobins / metabolism
Iron / blood,  metabolism*
Liver / embryology,  metabolism*
Maternal Age
Maternal Nutritional Physiological Phenomena
Placental Circulation
Pregnancy Outcome / veterinary*
Premature Birth
Reproductive Techniques, Assisted / veterinary*
Single Embryo Transfer / veterinary*
Grant Support
Reg. No./Substance:
0/Biological Markers; 0/Blood Proteins; 0/Hemoglobins; 50-28-2/Estradiol; 7439-89-6/Iron

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