| Liver iron excess in patients with hepatocellular carcinoma developed on viral C cirrhosis. | |
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MedLine Citation:
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PMID: 10764717 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Liver iron deposits are frequent in viral C cirrhotic patients but their role is not well defined. AIMS: To investigate the effect of liver iron excess on the prevalence of hepatocellular carcinoma (HCC) in patients with viral C cirrhosis. METHODS: Hepatic iron was evaluated retrospectively using a semiquantitative method in liver biopsies of 104 viral C cirrhotic patients, 48 with HCC and 56 controls (HCC free). Corrected total iron score (0-60) was defined by the sum of three scores: hepatocytic iron score (0-36), sinusoidal iron score (0-12), and portal iron score (0-12), multiplied by 3/3, 2/3, or 1/3 according to the heterogeneous iron localisation in the nodules. RESULTS: After adjustment for known risk factors for HCC, regression analysis showed that iron deposits (corrected total iron score >0) were more frequent in HCC patients than in controls (odds ratio 4.94; 95% confidence interval 1.59-15. 32; p=0.0056). The median of corrected total iron score was significantly higher in HCC patients than in controls (odds ratio 1. 092; 95% confidence interval 1.01-1.13; p=0.021). This liver iron overload was sinusoidal (odds ratio 5.2; 95% confidence interval 1. 82-15.11; p=0.0022). CONCLUSIONS: Liver iron deposition was more frequent and more important in viral C cirrhotic patients with HCC than in HCC free controls. Liver iron overload seems to contribute to the development of HCC in patients with viral C cirrhosis. |
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Authors:
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C Chapoutot; M Esslimani; Z Joomaye; J Ramos; P Perney; C Laurent; P Fabbro-Peray; D Larrey; J Domergue; F Blanc |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Gut Volume: 46 ISSN: 0017-5749 ISO Abbreviation: Gut Publication Date: 2000 May |
Date Detail:
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Created Date: 2000-06-01 Completed Date: 2000-06-01 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 2985108R Medline TA: Gut Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 711-4 Citation Subset: AIM; IM |
Affiliation:
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Service de Médecine Interne E, Hôpital St Eloi, Montpellier, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Carcinoma, Hepatocellular / complications*, metabolism, pathology Case-Control Studies Female Hepatitis C / complications*, metabolism Humans Iron Overload / complications*, metabolism Liver Cirrhosis / metabolism, pathology, virology Liver Neoplasms / complications*, metabolism, pathology Male Middle Aged Prevalence Regression Analysis |
| Comments/Corrections | |
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