Document Detail

Liver injury in the course of malaria.
MedLine Citation:
PMID:  11214108     Owner:  NLM     Status:  MEDLINE    
121 malaria cases treated in the Ward of Tropical Diseases of the Clinic of the Institute of Maritime and Tropical Medicine in Gdynia in the years 1993-1999 were analysed. About 37% of the patients showed symptoms of parenchymal liver injury manifested by increased bilirubin concentration, elevated transaminase, alkaline phosphatase and GGTP levels. Histopathological examination of the liver revealed the activation of cells of mononuclear phagocyte system, Kupffer's cells in particular, with the presence of granules of browny-black ,,malarial" pigment and iron deposits. In one fatal tropical malaria case, symptoms of disseminated intravascular coagulation were found along with a few lymphocytic infiltrations in portal spaces, and focal necrosis of hepatocytes. In some patients with the so-called ,,untypical" secondary liver lesions present in the histopathological examination, the toxic effect of antimalarial drugs should be taken into account. A liver biopsy is justified in patients manifesting multiple courses of malaria. It is indispensable in cases of suspected polyetiological changes in the liver and in cases of recompensation payment claims.
J Goljan; W Nahorski; I Felczak-Korzybska; J Górski; P Myjak
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International maritime health     Volume:  51     ISSN:  1641-9251     ISO Abbreviation:  Int Marit Health     Publication Date:  2000  
Date Detail:
Created Date:  2001-02-13     Completed Date:  2001-04-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  100958373     Medline TA:  Int Marit Health     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  30-9     Citation Subset:  IM    
Clinic of Internal, Occupational and Tropical Diseases, The Institute of Maritime and Tropical Medicine, Gdynia, Poland.
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MeSH Terms
Liver / pathology
Liver Diseases / epidemiology*,  etiology
Malaria / complications,  epidemiology*
Medical Records
Middle Aged
Naval Medicine / statistics & numerical data*
Nepal / epidemiology
Nigeria / epidemiology
Papua New Guinea / epidemiology
Retrospective Studies
Tropical Medicine / statistics & numerical data*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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