Document Detail

Liver in haemoglobin H disease.
MedLine Citation:
PMID:  5428045     Owner:  NLM     Status:  MEDLINE    
There have been no published reports on the liver of patients with haemoglobin H disease. In 11 Chinese patients studied (six male and five female) with haemoglobin H disease hepatic function and histology were studied. Liver function was normal in all cases; however, the gamma globulin level was raised in four cases, the increase being mainly in IgG in all cases and IgA in six cases. Liver histology showed that one case had portal cirrhosis, six cases mild fibrosis, and four cases no fibrosis. Haemosiderosis, mainly in the parenchymal cells of the peripheral lobules, was mild in one case, moderate in four, and severe in the remainder of the cases.
C B Keng; T K Khoo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gut     Volume:  11     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  1970 May 
Date Detail:
Created Date:  1970-08-27     Completed Date:  1970-08-27     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  423-9     Citation Subset:  AIM; IM    
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MeSH Terms
Bilirubin / blood
Hemoglobinopathies / complications,  pathology*
Hemosiderosis / complications
Immunoglobulin G / analysis
Immunoglobulin M / analysis
Iron / analysis
Liver / analysis,  pathology*
Liver Cirrhosis / complications,  pathology
Liver Function Tests
Middle Aged
Reg. No./Substance:
0/Immunoglobulin G; 0/Immunoglobulin M; 635-65-4/Bilirubin; 7439-89-6/Iron

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