Document Detail

Liver in Felty's syndrome.
MedLine Citation:
PMID:  5411618     Owner:  NLM     Status:  MEDLINE    
Liver function and histology, together with the haematological changes, were investigated in 12 patients with Felty's syndrome. Six of them were anaemic. The red cell mass was either normal or increased, and the anaemia was due to a considerable increase in the plasma volume. Two patients had increased haemolysis associated with red cell sequestration by the enlarged spleens.In eight patients liver function tests were abnormal, while in five the liver histology showed lymphocytic infiltration of the sinusoids and portal tracts together with portal tract fibrosis. One of these was later found to have a macronodular cirrhosis. In another there were apparent nodules without a true cirrhosis, and this appearance was also seen in two other patients with Felty's syndrome in whom histology was available. An increased blood flow through the spleen was found in the two patients examined.
L M Blendis; I D Ansell; K L Jones; E Hamilton; R Williams
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British medical journal     Volume:  1     ISSN:  0007-1447     ISO Abbreviation:  Br Med J     Publication Date:  1970 Jan 
Date Detail:
Created Date:  1970-03-05     Completed Date:  1970-03-05     Revised Date:  2010-10-26    
Medline Journal Info:
Nlm Unique ID:  0372673     Medline TA:  Br Med J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  131-5     Citation Subset:  AIM; IM    
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MeSH Terms
Anemia / complications
Child, Preschool
Felty's Syndrome / complications*
Liver / pathology
Liver Cirrhosis / pathology
Liver Diseases / complications*,  pathology
Liver Function Tests
Plasma Volume
Spleen / blood supply
Splenomegaly / complications

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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