Document Detail

Liver histology in patients on hemodialysis with chronic hepatitis C viral infection.
MedLine Citation:
PMID:  18603676     Owner:  NLM     Status:  MEDLINE    
Hepatitis C virus (HCV) is a major cause of chronic liver disease in patients on hemodialysis. As no useful noninvasive predictors of disease activity and fibrosis have been found, liver biopsy is essential in these patients to accurately assess the severity of disease and thus the prognosis and plan management. The present study was undertaken to assess the degree of severity of necroinflammatory changes and fibrosis in liver biopsies of patients on hemodialysis with chronic HCV infection. Liver biopsies obtained from 45 patients on hemodialysis with serological evidence of chronic hepatitis C were studied. The grading of necroinflammatory activity and staging of fibrosis were histologically assessed. The majority of patients (30, i.e. 66.7%) had mild disease with mild inflammatory activity and stage 0, 1 or 2 fibrosis. There was no significant correlation between the degree of fibrosis and the age of the patients (rs = 0.015), the duration of hemodialysis (rs = 0.047) or the presence of steatosis (rs = 0.064). There was a positive correlation between the presence of bile ductular proliferation and the severity of fibrosis (rs = 0.612). It was concluded that chronic HCV infection in hemodialysis patients is relatively mild early in its course. However, serial follow-up liver biopsies are mandatory to plan appropriate intervention strategies.
Vijaya V Mysorekar; Saraswathi G Rao; K C Mahadeva
Related Documents :
1375076 - Iron in granulocytes of nephrotic patients determined by zeeman electrothermal atomic a...
19260996 - Impaired regulation of serum hepcidin during phlebotomy in patients with chronic hepati...
21718466 - Antenatal screening for hiv, hepatitis b and syphilis in the netherlands is effective.
15814296 - Circulating markers of oxidative stress and liver fibrosis in sudanese subjects at risk...
1899876 - Detection of mycobacterium tuberculosis antigen 5 in cerebrospinal fluid by inhibition ...
17636766 - Nutritional interventions for reducing morbidity and mortality in people with hiv.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of pathology & microbiology     Volume:  51     ISSN:  0377-4929     ISO Abbreviation:  Indian J Pathol Microbiol     Publication Date:    2008 Apr-Jun
Date Detail:
Created Date:  2008-07-08     Completed Date:  2008-09-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7605904     Medline TA:  Indian J Pathol Microbiol     Country:  India    
Other Details:
Languages:  eng     Pagination:  182-5     Citation Subset:  IM    
Department of Pathology, M.S. Ramaiah Medical College, Bangalore, Karnataka, India.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Bile Ducts / pathology
Hepatitis C, Chronic / pathology*
Liver / pathology*
Middle Aged
Renal Dialysis*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Hepatobiliary tuberculosis in western India.
Next Document:  Clinically unsuspected Hodgkin's lymphoma diagnosed primarily from bone marrow trephine biopsy: repo...