| Liver histology of children with chronic hepatitis treated with interferon-alpha alone or in combination with lamivudine. | |
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MedLine Citation:
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PMID: 18030234 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To evaluate histological changes with interferon monotherapy or interferon plus lamivudine combination therapy in children with hepatitis B e antigen (HBeAg)-positive chronic hepatitis B. PATIENTS AND METHODS: 31 children aged 2-13 years were randomly treated with interferon (IFN) (group 1, n = 16) or IFN plus simultaneously started lamivudine (group 2, n = 15). IFN-alpha 2a was given 9 MU/m2 3 times per week for 6 months in each group; lamivudine was given 4 mg x kg(-1) x day(-1) for 24 months. Liver biopsy specimens were evaluated according to the Knodell score before therapy and after 24 months of therapy. Histological response was defined as a decrease in the histological activity index (HAI) score by at least 2 points. Efficacy of therapy was evaluated at 24 months of therapy in all children. RESULTS: Alanine aminotransferase normalization, HbeAg, and hepatitis B virus DNA clearance were not different. Complete response and histological response were 37.5%/62.5% and 40%/46.7% in groups 1 and 2, respectively (P = NS). At baseline and at 24 months of therapy, total HAI and components of HAI were not different in the 2 groups. In comparison with baseline, a significant decrease in scores of periportal +/- bridging necrosis was observed in group 1 (P = 0.01); periportal +/- bridging necrosis, intralobular degeneration, focal necrosis, and necroinflammation scores significantly decreased in group 2 (P = 0.04 and P = 0.02) at 24 months of therapy. CONCLUSIONS: The addition of lamivudine to IFN-alpha did not increase the effectiveness of the treatment in terms of complete and histological responses. Both therapies seemed to be effective in the regression of periportal +/- bridging necrosis. In addition, combination therapy was also effective in the regression of intralobular degeneration, focal necrosis, and necroinflammatory activity index. |
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Authors:
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Zarife Kuloglu; Ceyda Tuna Krsaçloglu; Aydan Kansu; Esra Erden; Nurten Girgin |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Journal of pediatric gastroenterology and nutrition Volume: 45 ISSN: 1536-4801 ISO Abbreviation: J. Pediatr. Gastroenterol. Nutr. Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-11-21 Completed Date: 2008-01-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8211545 Medline TA: J Pediatr Gastroenterol Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 564-8 Citation Subset: IM |
Affiliation:
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Department of Pediatric Gastroenterology, Ankara University School of Medicine, Ankara, Turkey. zarifekuloglu@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Anti-HIV Agents / therapeutic use* Antiviral Agents / therapeutic use* Biopsy Child Child, Preschool Drug Therapy, Combination Female Follow-Up Studies Hepatitis, Chronic / drug therapy*, pathology Humans Interferon-alpha / therapeutic use* Lamivudine / therapeutic use* Liver / drug effects, pathology* Male Necrosis Prospective Studies Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-HIV Agents; 0/Antiviral Agents; 0/Interferon-alpha; 134678-17-4/Lamivudine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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