Document Detail

Liver function from Y to Z.
MedLine Citation:
PMID:  23024981     Owner:  NLM     Status:  MEDLINE    
In the 1960s, my lab was interested in understanding how bilirubin and other organic anions are transferred from the plasma through the liver cell and into the bile. We performed gel filtration of liver supernatants and identified two protein fractions, designated Y and Z, which bound organic anions including bilirubin, and thus we proposed that they were involved in hepatic uptake of organic anions from plasma. Subsequently, the Y and Z proteins responsible for this binding activity were purified, cloned, and sequenced. Y was identified as a member of the glutathione S-transferase (GST) protein family and Z found to be a member of the fatty acid–binding protein (FABP) family. These proteins have since been shown to have additional surprising roles, but understanding of their full role in physiology and disease has not yet been achieved.
Irwin M Arias
Publication Detail:
Type:  Historical Article; Journal Article; Review    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  122     ISSN:  1558-8238     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-09-28     Completed Date:  2012-10-25     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2763-4     Citation Subset:  AIM; IM    
NIH, Bethesda, MD, USA.
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MeSH Terms
Bilirubin / metabolism
Fatty Acid-Binding Proteins / history,  metabolism
Glutathione Transferase / history,  metabolism
History, 20th Century
History, 21st Century
Liver / physiology*
Research / history
Reg. No./Substance:
0/Fatty Acid-Binding Proteins; 635-65-4/Bilirubin; EC Transferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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