Document Detail

Liver fibrosis: possible involvement of EMT.
MedLine Citation:
PMID:  17587827     Owner:  NLM     Status:  MEDLINE    
Hepatic fibrosis is a wound-healing process in the liver with acute and chronic injury and is characterized by an excess production and deposition of extracellular matrix components. Hepatic stellate cells as well as portal fibroblasts play a pivotal role in the liver fibrogenesis. Regarding the origin of these mesenchymal cells, two hypotheses emerge. One hypothesis argues in favor of BM-derived progenitor cells and a second hypothesis favors epithelial-mesenchymal transition (EMT) in the local formation of these mesenchymal cells from hepatic epithelium. In this short review, we describe (1) the principle mechanisms of hepatic fibrosis, (2) the cells which play a crucial role in hepatic fibrosis, and (3) the possible involvement of EMT in the process of hepatic fibrosis and carcinogenesis.
Tadashi Ikegami; Yining Zhang; Yasushi Matsuzaki
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cells, tissues, organs     Volume:  185     ISSN:  1422-6421     ISO Abbreviation:  Cells Tissues Organs (Print)     Publication Date:  2007  
Date Detail:
Created Date:  2007-06-25     Completed Date:  2007-07-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883360     Medline TA:  Cells Tissues Organs     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  213-21     Citation Subset:  IM    
Copyright Information:
2007 S. Karger AG, Basel
Division of Gastroenterology and Hepatology, Tokyo Medical University, Kasumigaura Hospital, Inashiki-gun, Japan.
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MeSH Terms
Epithelial Cells / pathology*
Fibroblasts / metabolism,  pathology
Liver Cirrhosis / pathology*
Liver Cirrhosis, Experimental / pathology*
Mesoderm / pathology*
Models, Biological

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