Document Detail

Liver fattening during feast and famine: an evolutionary paradox.
MedLine Citation:
PMID:  18054439     Owner:  NLM     Status:  MEDLINE    
Liver disease is one of the features of metabolic syndrome, one of the most occurring diseases of the twenty-first century. During food deprivation and starvation, adipose tissue elsewhere in the body delivers lipid components to the liver where they are stored as triacylglycerols (TG). Continuous and excessive food intake, on the other hand, leads to liver fattening (hepatic steatosis). In the long term this reaction is pathogenic mainly by inflammation reactions. We postulate the hypothesis in the evolutionary context that individuals with genes promoting the efficient deposition of fat during periods between famines (thrifty genes) in combination with a proinflammatory genotype would be favored and be selected during the course of evolution. Furthermore we postulate the hypothesis that the majority of man, living in a world were famine never comes, are physiologically not adapted to modern social behavior with abundance of food.
Vincent J T van Ginneken
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-12-03
Journal Detail:
Title:  Medical hypotheses     Volume:  70     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  2008  
Date Detail:
Created Date:  2008-03-26     Completed Date:  2008-07-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  924-8     Citation Subset:  IM    
Department of Anatomy and Embryology, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands.
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MeSH Terms
Adipose Tissue
Body Composition
Energy Metabolism
Fatty Liver / pathology
Food Deprivation
Liver Extracts / metabolism*
Macrophages / metabolism
Models, Biological
Triglycerides / metabolism*
Reg. No./Substance:
0/Liver Extracts; 0/Triglycerides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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