Document Detail

Liver failure due to antithyroid drugs: report of a case and literature review.
MedLine Citation:
PMID:  20960098     Owner:  NLM     Status:  MEDLINE    
Hyperthyroidism is a common endocrine disorder affecting 2% of females and 0.5% of males worldwide and antithyroid drugs constitute the first line of treatment in the majority of cases. These agents may cause severe adverse effects and among them liver failure, although rare, is a potential lethal one. This case illustrates the sudden and abrupt deterioration of hepatic function due to antithyroid drug administration. This case along with a concise literature review is presented aiming to increase the awareness of endocrinologists of possible fatal complications from the everyday use of common agents such as antithyroid drugs.
Sarantis Livadas; Xenofon Xyrafis; Frangiskos Economou; Georgios Boutzios; Maria Christou; Aristea Zerva; Athanasios Karachalios; Helen Palioura; Sotiria Palimeri; Evanthia Diamanti-Kandarakis
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2010-05-18
Journal Detail:
Title:  Endocrine     Volume:  38     ISSN:  1559-0100     ISO Abbreviation:  Endocrine     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-10-20     Completed Date:  2011-02-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9434444     Medline TA:  Endocrine     Country:  United States    
Other Details:
Languages:  eng     Pagination:  24-8     Citation Subset:  IM    
First Department of Internal Medicine, Laiko General Hospital, Medical School, University of Athens, Athens, Greece.
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MeSH Terms
Antithyroid Agents / adverse effects*
Hyperthyroidism / drug therapy*,  surgery
Liver Failure / chemically induced*
Methimazole / adverse effects*
Propylthiouracil / adverse effects*
Reg. No./Substance:
0/Antithyroid Agents; 51-52-5/Propylthiouracil; 60-56-0/Methimazole

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