Document Detail

Liver exposure to xenobiotics: the aging factor and potentials for functional foods.
MedLine Citation:
PMID:  16706665     Owner:  NLM     Status:  MEDLINE    
Hepatocytes isolated from 20- and 4-month Wistar rats and cultured with or without alpha-linolenic acid (LNA) were then added with nutraceutical YHK or sylibin before the test with iron or copper. Overall, YHK proved to be more effective than sylibin in Fe/Cu-induced peroxidative damage on normal and LNA-loaded hepatocytes (p < 0.05). YHK exerted a significant protection against DPPH radical-scavenging activity in the "old" group (p versus sylibin) and against lipophilic generators in both age groups (p < 0.05 versus sylibin). Both compounds were ineffective on age-related increase of surface-charge density. These preliminary data suggest that age per se enhances the vulnerability of hepatocytes to xenobiotics, whereas some safe nutraceuticals seem to exert significant protective effects.
F Marotta; P Lecroix; M Harada; K Masulair; P Safran; A Lorenzetti; S K Ono-Nita; P Marandola
Related Documents :
1797665 - Knowledge amongst adolescent girls about nutritive value of foods and diet during disea...
19333815 - Daily dietary intake of iron, copper, zinc and manganese in a spanish population.
7198375 - Iron availability from infant food supplements.
7623165 - Developmental zinc deficiency and behavior.
21299915 - Factors related to household food insecurity in the republic of korea.
10086925 - Biological mechanisms of dental fluorosis relevant to the use of fluoride supplements.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Rejuvenation research     Volume:  9     ISSN:  1549-1684     ISO Abbreviation:  Rejuvenation Res     Publication Date:  2006  
Date Detail:
Created Date:  2006-05-18     Completed Date:  2006-07-06     Revised Date:  2007-09-11    
Medline Journal Info:
Nlm Unique ID:  101213381     Medline TA:  Rejuvenation Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  338-41     Citation Subset:  IM    
Hepato-Gastroenterology Department, San Giuseppe Hospital, Milan, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cells, Cultured
Dietary Supplements*
Lipid Peroxidation
Liver / drug effects*
Lysosomes / metabolism
Oxidative Stress
Plant Extracts / pharmacology*
Rats, Wistar
Serum Albumin, Bovine
Xenobiotics / pharmacology*
alpha-Linolenic Acid
Reg. No./Substance:
0/Plant Extracts; 0/Serum Albumin, Bovine; 0/Xenobiotics; 463-40-1/alpha-Linolenic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Psychosocial aspects and zinc status: is there a relationship with successful aging?
Next Document:  The aging gut motility decay: may symbiotics be acting as "implantable" biologic pace-makers?