Document Detail

Liver exposure to xenobiotics: the aging factor and potentials for functional foods.
MedLine Citation:
PMID:  16706665     Owner:  NLM     Status:  MEDLINE    
Hepatocytes isolated from 20- and 4-month Wistar rats and cultured with or without alpha-linolenic acid (LNA) were then added with nutraceutical YHK or sylibin before the test with iron or copper. Overall, YHK proved to be more effective than sylibin in Fe/Cu-induced peroxidative damage on normal and LNA-loaded hepatocytes (p < 0.05). YHK exerted a significant protection against DPPH radical-scavenging activity in the "old" group (p versus sylibin) and against lipophilic generators in both age groups (p < 0.05 versus sylibin). Both compounds were ineffective on age-related increase of surface-charge density. These preliminary data suggest that age per se enhances the vulnerability of hepatocytes to xenobiotics, whereas some safe nutraceuticals seem to exert significant protective effects.
F Marotta; P Lecroix; M Harada; K Masulair; P Safran; A Lorenzetti; S K Ono-Nita; P Marandola
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Rejuvenation research     Volume:  9     ISSN:  1549-1684     ISO Abbreviation:  Rejuvenation Res     Publication Date:  2006  
Date Detail:
Created Date:  2006-05-18     Completed Date:  2006-07-06     Revised Date:  2007-09-11    
Medline Journal Info:
Nlm Unique ID:  101213381     Medline TA:  Rejuvenation Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  338-41     Citation Subset:  IM    
Hepato-Gastroenterology Department, San Giuseppe Hospital, Milan, Italy.
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MeSH Terms
Cells, Cultured
Dietary Supplements*
Lipid Peroxidation
Liver / drug effects*
Lysosomes / metabolism
Oxidative Stress
Plant Extracts / pharmacology*
Rats, Wistar
Serum Albumin, Bovine
Xenobiotics / pharmacology*
alpha-Linolenic Acid
Reg. No./Substance:
0/Plant Extracts; 0/Serum Albumin, Bovine; 0/Xenobiotics; 463-40-1/alpha-Linolenic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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