Document Detail

Liver disease in pregnancy.
MedLine Citation:
PMID:  10068707     Owner:  NLM     Status:  MEDLINE    
Acute viral hepatitis is the most common cause of jaundice in pregnancy. The course of acute hepatitis is unaffected by pregnancy, except in patients with hepatitis E and disseminated herpes simplex infections, in which maternal and fetal mortality rates are significantly increased. Chronic hepatitis B or C infections may be transmitted to neonates; however, hepatitis B virus transmission is effectively prevented with perinatal hepatitis B vaccination and prophylaxis with hepatitis B immune globulin. Cholelithiasis occurs in 6 percent of pregnancies; complications can safely be treated with surgery. Women with chronic liver disease or cirrhosis exhibit a higher risk of fetal loss during pregnancy. Preeclampsia is associated with HELLP (hemolysis, elevated liver enzymes and low platelet count) syndrome, acute fatty liver of pregnancy, and hepatic infarction and rupture. These rare diseases result in increased maternal and fetal mortality. Treatment involves prompt delivery, whereupon the liver disease quickly reverses. Therapy with penicillamine, trientine, prednisone or azathioprine can be safely continued during pregnancy.
C M Hunt; A I Sharara
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  American family physician     Volume:  59     ISSN:  0002-838X     ISO Abbreviation:  Am Fam Physician     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-03-22     Completed Date:  1999-03-22     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  1272646     Medline TA:  Am Fam Physician     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  829-36     Citation Subset:  AIM; IM    
Duke University Medical Center, Durham, North Carolina, USA.
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MeSH Terms
Cholelithiasis / diagnosis
Diagnosis, Differential
Fatty Liver / diagnosis
Hepatitis, Viral, Human / diagnosis
Jaundice / etiology
Liver Diseases / complications,  diagnosis*
Pre-Eclampsia / diagnosis
Pregnancy Complications / diagnosis*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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