| Liver disease in infants receiving total parenteral nutrition. | |
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MedLine Citation:
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PMID: 108658 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Progressive cholestasis and abnormal elevations of liver enzymes occurred in one third of 92, mostly preterm, newborn infants who received total parenteral nutrition (TPN) with protein hydrolysates, synthetic L-amino acids, and intravenous fat emulsion. The synthetic amino acid plus intravenous fat emulsion was not superior to the protein hydrolysate in preventing liver disease. The liver function returned to normal after discontinuation of TPN, which suggests a causal relationship. Hepatic microscopy was abnormal in 12 of 14 infants examined. The main features were progressive cholestasis and portal tract fibrosis and infiltration, which led to liver failure and death in two infants. In our experience, liver disease is the major metabolic complication of TPN in infants. |
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Authors:
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R Postuma; C L Trevenen |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Pediatrics Volume: 63 ISSN: 0031-4005 ISO Abbreviation: Pediatrics Publication Date: 1979 Jan |
Date Detail:
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Created Date: 1979-07-28 Completed Date: 1979-07-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376422 Medline TA: Pediatrics Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 110-5 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alkaline Phosphatase
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analysis Bilirubin / blood Humans Infant Infant, Newborn Infant, Premature, Diseases / etiology*, pathology Liver / enzymology, pathology Liver Diseases / etiology*, pathology Parenteral Nutrition / adverse effects* Parenteral Nutrition, Total / adverse effects* |
| Chemical | |
Reg. No./Substance:
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635-65-4/Bilirubin; EC 3.1.3.1/Alkaline Phosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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