Document Detail


Liver diffusivity in healthy volunteers and patients with chronic liver disease: comparison of breathhold and free-breathing techniques.
MedLine Citation:
PMID:  22034200     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To compare liver ADC obtained with breathhold and free-breathing diffusion weighted imaging (DWI) in healthy volunteers and patients with liver disease.
MATERIALS AND METHODS: Twenty-eight subjects, 12 healthy volunteers and 16 patients (9 NAFLD, 7 chronic active HCV), underwent breathhold (BH) and free-breathing (FB) DWI MRI at 1.5 Tesla. Pearson's correlation coefficient was used to determine correlation while paired t-tests assessed differences between BH and FB ADC. Estimated bias was calculated using the Bland-Altman method.
RESULTS: Liver ADC (×10(-3) mm(2) /s) was lower on BH for all groups (mean difference 0.36 ± 0.20; P < 0.01). ADC was higher in healthy volunteers (BH 1.80 ± 0.18; FB 2.24 ± 0.20) compared with NAFLD patients (BH 1.43 ± 0.27; FB 1.78 ± 0.28) (P < 0.001) and HCV patients (BH 1.63 ± 0.191; FB 1.88 ± 0.12). Overall correlation between BH and FB ADC was (r = 0.75), greatest in NAFLD (r = 0.90) compared with the correlation in HCV (r = 0.24) and healthy subjects (r = 0.34). Bland-Altman plots did not show agreement in mean absolute difference and estimated bias between subjects.
CONCLUSION: Correlation between BH and FB liver ADC is moderate indicating that BH and FB should not be used interchangeably. Additionally, the lower ADC values in BH versus FB should be accounted for when comparing different liver DWI studies.
Authors:
Mamak Eatesam; Susan M Noworolski; Phyllis C Tien; Michelle Nystrom; Jennifer L Dodge; Raphael B Merriman; Aliya Qayyum
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-10-27
Journal Detail:
Title:  Journal of magnetic resonance imaging : JMRI     Volume:  35     ISSN:  1522-2586     ISO Abbreviation:  J Magn Reson Imaging     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-16     Completed Date:  2012-04-17     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  9105850     Medline TA:  J Magn Reson Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  103-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Wiley-Liss, Inc.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Case-Control Studies
Diffusion
Diffusion Magnetic Resonance Imaging / methods
End Stage Liver Disease / pathology*
Fatty Liver / complications,  diagnosis*
Female
Hepatitis C / complications,  diagnosis*
Humans
Image Processing, Computer-Assisted / methods
Liver / pathology*
Magnetic Resonance Imaging / methods
Male
Middle Aged
Models, Statistical
Respiration
Grant Support
ID/Acronym/Agency:
K23 AI-66943/AI/NIAID NIH HHS; M01-RR-00083/RR/NCRR NIH HHS; R01 DK061738-SI/DK/NIDDK NIH HHS; R01 DK074718/DK/NIDDK NIH HHS; R01 DK074718-01/DK/NIDDK NIH HHS; R01 DK074718-04/DK/NIDDK NIH HHS; U01 AI-34989/AI/NIAID NIH HHS; U01-AI-31834/AI/NIAID NIH HHS; U01-AI-34989/AI/NIAID NIH HHS; U01-AI-34993/AI/NIAID NIH HHS; U01-AI-34994/AI/NIAID NIH HHS; U01-AI-35004/AI/NIAID NIH HHS; U01-AI-42590/AI/NIAID NIH HHS; U01-HD-32632/HD/NICHD NIH HHS; UL1 RR024131/RR/NCRR NIH HHS
Comments/Corrections

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