Document Detail

Liver desaturase activities and FA composition in monkeys. Effect of a low-protein diet.
MedLine Citation:
PMID:  12880108     Owner:  NLM     Status:  MEDLINE    
The aim of the present study was to measure delta9-, delta6-, and delta5-desaturase activities in liver microsomes, as well as phospholipid FA composition of liver and erythrocytes in monkeys fed a control or low-protein diet during the postweaning period. Ten Saimiri sciureus boliviensis (Cebidae) of both sexes were employed; at 12 mon of age they were separated into two groups fed ad libitum on a control or a low-protein diet for 24 mon. Saimiri sciureus had active delta9, delta6, and delta5 liver desaturase enzymes, and these activities were influenced by the diet. A low-protein diet produced a significant reduction in delta5-desaturation capacity, an increase in delta9-desaturase activity, and no change in delta6-desaturase activity (P < 0.05). These changes, evoked by protein deprivation, were reflected in the liver phospholipid FA composition. Increases in the proportion of saturated FA and in monounsaturated oleic acid (18:1n-9) and a decrease in the proportion of PUFA of the n-6 and n-3 series were produced in the animals fed a low-protein diet (P < 0.0001).
María C Marín; Héctor M Pucciarelli; María J T de Alaniz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lipids     Volume:  38     ISSN:  0024-4201     ISO Abbreviation:  Lipids     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-07-25     Completed Date:  2004-03-30     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  United States    
Other Details:
Languages:  eng     Pagination:  525-9     Citation Subset:  IM    
Instituto de Investigaciones Bioquímicas de La Plata (INIBIOLP), Facultad de Ciencias Médicas, Universidad Nacional de La Plata, (1900) La Plata, Buenos Aires, Argentina.
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MeSH Terms
Body Weight / drug effects
Diet, Protein-Restricted*
Erythrocytes / chemistry,  drug effects
Fatty Acid Desaturases / metabolism*
Fatty Acids / analysis*
Linoleoyl-CoA Desaturase
Liver / chemistry,  drug effects,  enzymology*
Microsomes, Liver / drug effects,  enzymology
Phospholipids / chemistry
Stearoyl-CoA Desaturase / metabolism
Reg. No./Substance:
0/Fatty Acids; 0/Phospholipids; EC 1.14.19.-/Fatty Acid Desaturases; EC Desaturase; EC Desaturase; EC 1.14.99.-/delta-5 fatty acid desaturase

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