Document Detail


Liver desaturase activities and FA composition in monkeys. Effect of a low-protein diet.
MedLine Citation:
PMID:  12880108     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the present study was to measure delta9-, delta6-, and delta5-desaturase activities in liver microsomes, as well as phospholipid FA composition of liver and erythrocytes in monkeys fed a control or low-protein diet during the postweaning period. Ten Saimiri sciureus boliviensis (Cebidae) of both sexes were employed; at 12 mon of age they were separated into two groups fed ad libitum on a control or a low-protein diet for 24 mon. Saimiri sciureus had active delta9, delta6, and delta5 liver desaturase enzymes, and these activities were influenced by the diet. A low-protein diet produced a significant reduction in delta5-desaturation capacity, an increase in delta9-desaturase activity, and no change in delta6-desaturase activity (P < 0.05). These changes, evoked by protein deprivation, were reflected in the liver phospholipid FA composition. Increases in the proportion of saturated FA and in monounsaturated oleic acid (18:1n-9) and a decrease in the proportion of PUFA of the n-6 and n-3 series were produced in the animals fed a low-protein diet (P < 0.0001).
Authors:
María C Marín; Héctor M Pucciarelli; María J T de Alaniz
Related Documents :
2985678 - Dietary change: prescription vs. goal setting.
14870928 - Maternal dietary fa modulate the long-chain n-3 pufa status of chick cardiac tissue.
2008868 - The mediterranean-type diet: is there a need for further modification?
20484448 - Dietary n-3 and n-6 polyunsaturated fatty acid intake interacts with fads1 genetic vari...
10644638 - Effects of feeding on metabolism, gas transport, and acid-base balance in the bullfrog ...
21691578 - Antioxidant oils and salmonella enterica typhimurium reduce tumor in an experimental mo...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lipids     Volume:  38     ISSN:  0024-4201     ISO Abbreviation:  Lipids     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-07-25     Completed Date:  2004-03-30     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  United States    
Other Details:
Languages:  eng     Pagination:  525-9     Citation Subset:  IM    
Affiliation:
Instituto de Investigaciones Bioquímicas de La Plata (INIBIOLP), Facultad de Ciencias Médicas, Universidad Nacional de La Plata, (1900) La Plata, Buenos Aires, Argentina. mmarin@atlas.med.unlp.edu.ar
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Body Weight / drug effects
Diet, Protein-Restricted*
Erythrocytes / chemistry,  drug effects
Fatty Acid Desaturases / metabolism*
Fatty Acids / analysis*
Female
Linoleoyl-CoA Desaturase
Liver / chemistry,  drug effects,  enzymology*
Male
Microsomes, Liver / drug effects,  enzymology
Phospholipids / chemistry
Saimiri
Stearoyl-CoA Desaturase / metabolism
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Phospholipids; EC 1.14.19.-/Fatty Acid Desaturases; EC 1.14.19.1/Stearoyl-CoA Desaturase; EC 1.14.19.3/Linoleoyl-CoA Desaturase; EC 1.14.99.-/delta-5 fatty acid desaturase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Pitavastatin ameliorates severe hepatic steatosis in aromatase-deficient (Ar-/-) mice.
Next Document:  Regulation by carbohydrate and clofibric acid of palmitoyl-CoA chain elongation in the liver of rats...