Document Detail

Liver-derived matrix metalloproteinase-9 (gelatinase B) recruits progenitor cells from bone marrow into the blood circulation.
MedLine Citation:
PMID:  12673046     Owner:  NLM     Status:  MEDLINE    
Matrix metalloproteinases (MMPs) are involved in invasive cell behavior, embryonic development and organ remodeling. In this report, we investigated the role of liver-derived MMP-9 in the in vivo system at liver injury. Liver injury induced MMP-9 expression in the liver 3 to 12 h after intravenous administration of anti-Fas antibody, followed by the expression of the activity and the protein detected by zymography and Western blotting, respectively, in the blood circulation. Interestingly, the MMP-9 expression was accompanied by the recruitment of hematopoietic progenitor cells from bone marrow into the circulation. The recruitment was blocked by a specific MMP-9 inhibitor, R94138, which did not affect the Fas-mediated liver injury or induced expression of MMP-9. Compulsive expression of mutant active MMP-9 in the liver also recruited the progenitor cells into the circulation. In contrast, partial hepatectomy, which treatment does not directly injure hepatocytes, did not recruit progenitor cells despite the increased expression of MMP-9 in the circulation. These results suggest that liver-derived MMP-9 induced by liver injury plays an essential role in the recruitment of hematopoietic progenitor cells from bone marrow into the blood circulation.
Yoshifumi Watanabe; Takahiro Haruyama; Toshihiro Akaike
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biological & pharmaceutical bulletin     Volume:  26     ISSN:  0918-6158     ISO Abbreviation:  Biol. Pharm. Bull.     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-04-03     Completed Date:  2003-11-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9311984     Medline TA:  Biol Pharm Bull     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  564-8     Citation Subset:  IM    
Department of Biomolecular Engineering, Tokyo Institute of Technology, Yokohama, Japan.
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MeSH Terms
Blood Circulation / physiology*
Bone Marrow Cells / enzymology*
Enzyme Induction / physiology
Gene Expression Regulation, Enzymologic / physiology
Hematopoietic Stem Cells / enzymology*
Liver / enzymology*,  pathology
Matrix Metalloproteinase 9 / biosynthesis,  genetics,  physiology*
Mice, Inbred BALB C
Reg. No./Substance:
EC Metalloproteinase 9

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