Document Detail


Liver damage from flucloxacillin, cloxacillin and dicloxacillin.
MedLine Citation:
PMID:  1506634     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We describe a case of severe cholestatic liver disease, which persisted for 7 years, and was probably induced by flucloxacillin. We also report a survey of 77 liver reactions which were probably or possibly induced by penicillinase-resistant penicillins and spontaneously reported to the Swedish Adverse Drug Reactions Advisory Committee. The reactions were usually cholestatic with a tendency to a protracted course. There is some evidence for an immunoallergic idiosyncratic reaction. The incidence of reported liver reactions was estimated from sales data to be 1.6-2.9 per million DDD (defined daily doses) or, for flucloxacillin 1:11,000-1:30,000 prescriptions. Female sex, age and high daily doses seemed to be associated with higher risk of liver reactions from flucloxacillin.
Authors:
R Olsson; B E Wiholm; C Sand; L Zettergren; R Hultcrantz; M Myrhed
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of hepatology     Volume:  15     ISSN:  0168-8278     ISO Abbreviation:  J. Hepatol.     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-09-22     Completed Date:  1992-09-22     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8503886     Medline TA:  J Hepatol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  154-61     Citation Subset:  IM    
Affiliation:
Department of Medicine II, University of Gothenburg, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Cholestasis / chemically induced,  epidemiology,  pathology
Cloxacillin / adverse effects*
Dicloxacillin / adverse effects*
Dose-Response Relationship, Drug
Drug-Induced Liver Injury*
Female
Floxacillin / adverse effects*
Humans
Liver / drug effects*,  pathology
Middle Aged
Risk Factors
Sweden / epidemiology
Time Factors
Chemical
Reg. No./Substance:
3116-76-5/Dicloxacillin; 5250-39-5/Floxacillin; 61-72-3/Cloxacillin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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