| Liver damage from flucloxacillin, cloxacillin and dicloxacillin. | |
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MedLine Citation:
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PMID: 1506634 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We describe a case of severe cholestatic liver disease, which persisted for 7 years, and was probably induced by flucloxacillin. We also report a survey of 77 liver reactions which were probably or possibly induced by penicillinase-resistant penicillins and spontaneously reported to the Swedish Adverse Drug Reactions Advisory Committee. The reactions were usually cholestatic with a tendency to a protracted course. There is some evidence for an immunoallergic idiosyncratic reaction. The incidence of reported liver reactions was estimated from sales data to be 1.6-2.9 per million DDD (defined daily doses) or, for flucloxacillin 1:11,000-1:30,000 prescriptions. Female sex, age and high daily doses seemed to be associated with higher risk of liver reactions from flucloxacillin. |
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Authors:
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R Olsson; B E Wiholm; C Sand; L Zettergren; R Hultcrantz; M Myrhed |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of hepatology Volume: 15 ISSN: 0168-8278 ISO Abbreviation: J. Hepatol. Publication Date: 1992 May |
Date Detail:
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Created Date: 1992-09-22 Completed Date: 1992-09-22 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8503886 Medline TA: J Hepatol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 154-61 Citation Subset: IM |
Affiliation:
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Department of Medicine II, University of Gothenburg, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cholestasis
/
chemically induced,
epidemiology,
pathology Cloxacillin / adverse effects* Dicloxacillin / adverse effects* Dose-Response Relationship, Drug Drug-Induced Liver Injury* Female Floxacillin / adverse effects* Humans Liver / drug effects*, pathology Middle Aged Risk Factors Sweden / epidemiology Time Factors |
| Chemical | |
Reg. No./Substance:
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3116-76-5/Dicloxacillin; 5250-39-5/Floxacillin; 61-72-3/Cloxacillin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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