| Liver cirrhosis and arterial hypertension. | |
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MedLine Citation:
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PMID: 16521178 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Characteristic findings in patients with cirrhosis are vasodilatation with low overall systemic vascular resistance, high arterial compliance, increased cardiac output, secondary activation of counter-regulatory systems (renin-angiotensin-aldosterone system, sympathetic nervous system, release of vasopressin), and resistance to vasopressors. The vasodilatory state is mediated through adrenomedullin, calcitonin gene-related peptide, nitric oxide, and other vasodilators, and is most pronounced in the splanchnic area. This constitutes an effective (although relative) counterbalance to increased arterial blood pressure. This review considers the alterations in systemic hemodynamics in patients with cirrhosis in relation to essential hypertension and arterial hypertension of the renal origin. Subjects with arterial hypertension (essential, secondary) may become normotensive during the development of cirrhosis, and arterial hypertension is rarely manifested in patients with cirrhosis, even in cases with renovascular disease and high circulating renin activity. There is much dispute as to the understanding of homoeostatic regulation in cirrhotic patients with manifest arterial hypertension. This most likely includes the combination of vasodilatation and vasoconstriction in parallel. |
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Authors:
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Jens H Henriksen; Soren Moller |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: World journal of gastroenterology : WJG Volume: 12 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2006 Feb |
Date Detail:
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Created Date: 2006-03-07 Completed Date: 2006-05-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
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Languages: eng Pagination: 678-85 Citation Subset: IM |
Affiliation:
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Department of Clinical Physiology, 239 Hvidovre University Hospital, DK-2650 Hvidovre, Denmark. jens.h.henriksen@hh.hosp.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Pressure Blood Volume Heart / physiopathology Humans Hypertension / complications*, physiopathology Kidney / physiopathology Liver Circulation Liver Cirrhosis / complications*, physiopathology Neurotransmitter Agents / physiology Splanchnic Circulation Vascular Resistance |
| Chemical | |
Reg. No./Substance:
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0/Neurotransmitter Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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