Document Detail


Liver cancers in Mayak workers.
MedLine Citation:
PMID:  10956429     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Liver cancer mortality risks were evaluated in 11,000 workers who started working at the "Mayak" Production Association in 1948-1958 and who were exposed to both internally deposited plutonium and external gamma radiation. Comparisons with Russian liver cancer incidence rates indicate excess risk, especially among those with detectable plutonium body burdens and among female workers in the plutonium plant. Comparisons within the Mayak worker cohort which evaluate the role of plutonium body burden with adjustment for cumulative external dose indicate excess risk among workers with burdens estimated to exceed 7.4 kBq (relative risk = 17; 95% CI = 8. 0-36) and among workers in the plutonium plant who did not have routine plutonium monitoring data based on urine measurements (relative risk = 2.8; 95% CI = 1.3-6.2). In addition, analyses treating the estimated plutonium body burden as a continuous variable indicate increasing risk with increasing burden (P < 0.001). Relative risks tended to be higher for females than for males, probably because of the lower baseline risk and the higher levels of plutonium measured in females. Because of limitations in current plutonium dosimetry, no attempt was made to quantify liver cancer risks from plutonium in terms of organ dose, and risk from external dose could not be reliably evaluated.
Authors:
E S Gilbert; N A Koshurnikova; M Sokolnikov; V F Khokhryakov; S Miller; D L Preston; S A Romanov; N S Shilnikova; K G Suslova; V V Vostrotin
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Radiation research     Volume:  154     ISSN:  0033-7587     ISO Abbreviation:  Radiat. Res.     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-09-28     Completed Date:  2000-09-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0401245     Medline TA:  Radiat Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  246-52     Citation Subset:  IM; S    
Affiliation:
Radiation Epidemiology Branch, National Cancer Institute, Bethesda, Maryland 20852, USA.
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MeSH Terms
Descriptor/Qualifier:
Body Burden
Carcinoma, Hepatocellular / epidemiology*,  etiology,  mortality
Cholangiocarcinoma / epidemiology*,  etiology,  mortality
Cohort Studies
England / epidemiology
Female
Gamma Rays / adverse effects*
Hemangiosarcoma / epidemiology*,  etiology,  mortality
Humans
Liver / radiation effects
Liver Neoplasms / epidemiology*,  etiology,  mortality
Male
Middle Aged
Neoplasms, Radiation-Induced / epidemiology*,  etiology,  mortality
Nuclear Energy*
Occupational Diseases / epidemiology*,  etiology,  mortality
Occupational Exposure*
Plutonium / adverse effects*,  urine
Radiometry
Risk
Russia / epidemiology
Sex Factors
United States / epidemiology
Grant Support
ID/Acronym/Agency:
CA66749/CA/NCI NIH HHS; N01-CP-51025/CP/NCI NIH HHS; N01-CP-81034/CP/NCI NIH HHS
Chemical
Reg. No./Substance:
7440-07-5/Plutonium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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