Document Detail

Liver biopsy methods for pediatric oncology patients.
MedLine Citation:
PMID:  10929368     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Liver biopsy is a high-risk procedure in oncology patients, and optimal methods for children have not been established. OBJECTIVE: To assess the effectiveness and safety of two methods of performing liver biopsy in pediatric oncology patients. MATERIALS AND METHODS: Between May 1997 and July 1999, 51 liver biopsies (22 percutaneous and 29 transjugular) were performed. The 22 percutaneous biopsies (13 focal hepatic lesions and 9 general liver biopsies) were performed under sonographic guidance; 21 used a spring-loaded needle (usually 18 G). In 21 patients, a coaxial sheath was used to inject a slurry of microfibrillar collagen into the needle track. The 29 transjugular general liver biopsies were performed with a 19-G spring-loaded needle, under sonographic and fluoroscopic guidance. The transjugular technique was used for children with thrombocytopenia, coagulopathy, ascites, or recent bone-marrow transplantation. RESULTS: All biopsies yielded sufficient tissue for diagnostic studies. Bleeding occurred after 3 of 21 percutaneous biopsies, despite coaxial track embolization. No bleeding or other major complication occurred after transjugular biopsy. CONCLUSION: Coaxial percutaneous biopsy with track embolization was effective, but was not complication-free; it should be reserved for focal lesions or for patients at low risk of bleeding. Transjugular liver biopsy is safe and effective for use in high-risk pediatric oncology patients.
F A Hoffer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatric radiology     Volume:  30     ISSN:  0301-0449     ISO Abbreviation:  Pediatr Radiol     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-12-20     Completed Date:  2000-12-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0365332     Medline TA:  Pediatr Radiol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  481-8     Citation Subset:  IM    
Department of Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, TN 38105-2794, USA.
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MeSH Terms
Biopsy / adverse effects,  methods*
Child, Preschool
Hemorrhage / etiology
Liver Diseases / diagnosis*
Neoplasms / complications*
Prospective Studies
Ultrasonography, Doppler, Color
Grant Support

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