Document Detail

Liver autoantibodies in patients with scleroderma.
MedLine Citation:
PMID:  20931345     Owner:  NLM     Status:  In-Process    
Association between autoimmune liver diseases and scleroderma has been described. The purpose of this study was to study the prevalence of antimithocondrial antibody (AMA), antismooth muscle antibodies (SMA), and liver-kidney-microsomal (LKM-1) autoantibody in a cohort of 63 scleroderma patients and 100 healthy controls. The autoantibodies AMA, SMA, and LKM were determined by indirect immunofluorescence. Patients' charts were reviewed for demographic data, scleroderma form, and clinical and anti-nuclear antibody profile, aiming a comparison between patients with and without liver autoantibodies. Nine patients (14.3%) were positive for at least one of the liver autoantibodies; only one patient had both AMA and SMA positive. Antibody SMA was positive in 6.4% (4/63) patients; AMA was present in 9.52% (6/63) of them; none were positive to LKM-1. In the control group just one patient (1%) was SMA positive; the other autoantibodies were negative. There is an increased prevalence of liver autoantibodies in patients with scleroderma than in control population. These patients should be carefully followed for liver dysfunction.
Thelma L Skare; Renato M Nisihara; Osvaldo Haider; Pedro M Azevedo; Shirley R R Utiyama
Related Documents :
20339175 - Serum paraoxonase 1 activity status in patients with liver disorders.
19202445 - Tuberculosis in liver transplant recipients: a single brazilian center experience.
8675425 - Doppler ultrasound of the hepatic artery and vein performed daily in the first two week...
20076815 - The long-term evolution of chronic hepatitis b acquired in childhood.
7954755 - Isolated headache as the presenting clinical manifestation of intracranial tumors: a pr...
19235885 - Crohn's disease in a southern european country: montreal classification and clinical ac...
Publication Detail:
Type:  Journal Article     Date:  2010-10-08
Journal Detail:
Title:  Clinical rheumatology     Volume:  30     ISSN:  1434-9949     ISO Abbreviation:  Clin. Rheumatol.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211469     Medline TA:  Clin Rheumatol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  129-32     Citation Subset:  IM    
Department of Medicine, Evangelical University, Curitiba, Paraná, Brazil.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Reduced expression of intestinal N-acetylglutamate synthase in suckling piglets: a novel molecular m...
Next Document:  The effects of strength and endurance training in patients with rheumatoid arthritis.