Document Detail

Liver adenomatosis: reappraisal, diagnosis, and surgical management: eight new cases and review of the literature.
MedLine Citation:
PMID:  10636105     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Liver adenomatosis (LA) is a rare disease originally defined by Flejou et al in 1985 from a series of 13 cases. In 1998, 38 cases were available for analysis, including eight personal cases. The aim of this study was to review and reappraise the characteristics of this rare liver disease and to discuss diagnosis and therapeutic options.
BACKGROUND: LA was defined as the presence of >10 adenomas in an otherwise normal parenchyma. Neither female predominance nor a relation with estrogen/progesterone intake has been noted. Natural progression is poorly known.
METHODS: The clinical presentation, evolution, histologic characteristics, and therapeutic options and results were analyzed based on a personal series of eight new cases and an updated review of the literature.
RESULTS: From a diagnostic standpoint, two forms of liver adenomatosis with different presentations and evolution can be defined: a massive form and a multifocal form. The role of estrogen and progesterone is reevaluated. The risks of hemorrhage and malignant transformation are of major concern. In the authors' series, liver transplantation was indicated in two young women with the massive, aggressive form, and good results were obtained.
CONCLUSION: Liver adenomatosis is a rare disease, more common in women, where outcome and evolution vary and are exacerbated by estrogen intake. Most often, conservative surgery is indicated. Liver transplantation is indicated only in highly symptomatic and aggressive forms of the disease.
L Chiche; T Dao; E Salamé; M P Galais; N Bouvard; G Schmutz; P Rousselot; P Bioulac-Sage; P Ségol; M Gignoux
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annals of surgery     Volume:  231     ISSN:  0003-4932     ISO Abbreviation:  Ann. Surg.     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-01-24     Completed Date:  2000-01-24     Revised Date:  2013-06-11    
Medline Journal Info:
Nlm Unique ID:  0372354     Medline TA:  Ann Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  74-81     Citation Subset:  AIM; IM    
Department of Hepatobiliary Surgery, University Hospital of Caen, France.
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MeSH Terms
Adenoma, Liver Cell / genetics,  pathology,  surgery*
Cell Transformation, Neoplastic / pathology
Liver / pathology
Liver Neoplasms / genetics,  pathology,  surgery*
Liver Transplantation
Middle Aged
Tomography, X-Ray Computed
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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