| Liver Patt1 deficiency protects male mice from Age-associated but not high-fat diet-induced hepatic steatosis. | |
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MedLine Citation:
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PMID: 22231784 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Patt1 is a newly identified protein acetyltransferase, which is highly expressed in liver. However, the role of Patt1 in liver is still unclear. We generated Patt1 liver-specific knockout mice, and mainly measured the effect of hepatic Patt1 deficiency on lipid metabolism. Hepatic Patt1 deficiency in male mice markedly decreases fat mass, and dramatically alleviates age-associated accumulation of lipid droplets in liver. Moreover, hepatic Patt1 abrogation in male mice significantly reduces the liver triglyceride and free fatty acid levels, but has no effect on liver cholesterol level, liver weight and liver function. Consistently, primary cultured Patt1-deficient hepatocytes are resistant to palmitic acid-induced lipid accumulation, but liver Patt1 deficiency fails to protect male mice from high-fat diet-induced hepatic steatosis. Further studies show that hepatic Patt1 deficiency decreases fatty acid uptake, reduces lipid synthesis and enhances fatty acid oxidation, which may contribute to the attenuated hepatic steatosis in Patt1 liver-specific knockout mice. These results demonstrate that Patt1 plays an important role in hepatic lipid metabolism, and has implications toward resolving age-associated hepatic steatosis. |
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Authors:
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Yang Liu; Daizhan Zhou; Fang Zhang; Yanyang Tu; Yulei Xia; Hui Wang; Ben Zhou; Yi Zhang; Jingxia Wu; Xiang Gao; Zhishui He; Qiwei Zhai |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-9 |
Journal Detail:
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Title: Journal of lipid research Volume: - ISSN: 0022-2275 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376606 Medline TA: J Lipid Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Chinese Academy of Sciences, China; |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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