| Liver MRI in the hepatocyte phase with gadolinium-EOB-DTPA: Does increasing the flip angle improve conspicuity and detection rate of hypointense lesions? | |
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MedLine Citation:
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PMID: 22034383 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: To compare conspicuity and detection rate of hypointense lesions on T1-weighted (T1w) gradient echo (GRE) sequences with low and high flip angles (FA) in hepatocyte phase magnetic resonance imaging (MRI) using gadoxetate disodium. MATERIALS AND METHODS: This Health Insurance Portability and Accountability Act (HIPAA)-compliant study was Institutional Review Board (IRB)-approved. The study population consisted of patients with hypointense liver lesions undergoing MRI with gadoxetate disodium, with hepatocyte-phase fat suppressed 3D T1w GRE sequences at both low (10-12°) and high (30-35°) FA. Contrast-to-noise ratios (CNRs) were calculated for liver parenchyma vs. large lesions and common bile duct (CBD) vs. liver. Three radiologists each assigned a conspicuity score (CS) for each lesion detected at low or high FA. Paired Student's t-tests compared the lesion detection (LD) rate using only the hepatocyte phase data set compared with the entire MRI examination, and CS for low and high FA. RESULTS: In all, 57 large and 70 small lesions were identified in 18 patients. Average LD and CS were significantly greater at high FA versus low FA overall (LD 89.0% vs. 79.5%; CS 2.8 vs. 2.2; P < 0.05) and for small lesions (81.4% vs. 65.7%; 2.5 vs. 1.8; P < 0.05). Average liver-to-lesion CNR for large lesions and CBD-to-liver CNR was significantly greater at high FA (P < 0.05). CONCLUSION: Increasing the FA in hepatocyte phase MRI with gadoxetate disodium improves hypointense lesion detection and conspicuity, particularly for small lesions. J. Magn. Reson. Imaging 2011;. © 2011 Wiley Periodicals, Inc. |
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Authors:
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Mustafa R Bashir; Daniela B Husarik; Tim J Ziemlewicz; Rajan T Gupta; Daniel T Boll; Elmar M Merkle |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-27 |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: - ISSN: 1522-2586 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Wiley-Liss, Inc. |
Affiliation:
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Department of Radiology, Duke University Medical Center, Durham, North Carolina, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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