Document Detail

Liver L-gulonolactone oxidase activity and tissue ascorbic acid concentrations in nursing pigs and the effect of various weaning ages.
MedLine Citation:
PMID:  11435521     Owner:  NLM     Status:  MEDLINE    
In Experiment 1, we evaluated liver L-gulono-gamma-lactone oxidase (GLO) activity and tissue concentration of ascorbic acid in young pigs from birth to weaning (14 d) and through a 28-d postweaning period; in Experiment 2, we evaluated the effect of three weaning ages on these measurements. Sow colostrum and milk collected in both experiments demonstrated a linear decline (P < 0.01) in ascorbic acid concentration as lactation progressed. In Experiment 1, three pigs were killed at 0, 3, 7, 14, 21, 28, 35 and 42 d of age for determining liver GLO activity and serum and tissue ascorbic acid. Liver GLO activity decreased by 80% from 0 to 3 d of age and remained low until d 14 (weaning). After weaning, liver GLO activity increased linearly (P < 0.01). Tissue ascorbic acid concentrations decreased during the nursing period and again after weaning, but then increased to 42 d of age (P < 0.01). In Experiment 2, pigs were weaned at 10, 17 or 24 d of age. Three pigs from each group were killed at weaning and at each week postweaning until 38 d of age. Liver GLO activity was low during the nursing period but increased linearly (P < 0.01) for each group during the subsequent postweaning period. Pig serum and tissue ascorbic acid concentrations increased postweaning in each group. These results suggest that a factor in sow's milk, possibly ascorbic acid, suppressed liver GLO activity of nursing pigs but upon weaning, liver GLO activity of pigs increased in a linear manner (P < 0.01).
S Ching; D C Mahan; K Dabrowski
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The Journal of nutrition     Volume:  131     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-07-03     Completed Date:  2001-08-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2002-6     Citation Subset:  IM    
Department of Animal Sciences, The Ohio State University and The Ohio Agricultural Research and Development Center, Columbus, OH 43210-1094, USA.
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MeSH Terms
Age Factors
Animal Feed
Animals, Newborn
Animals, Suckling / metabolism*
Ascorbic Acid / analysis,  metabolism*
Colostrum / chemistry
L-Gulonolactone Oxidase
Liver / enzymology*
Milk / chemistry
Nutritional Status
Sugar Alcohol Dehydrogenases / metabolism*
Swine / metabolism*
Reg. No./Substance:
50-81-7/Ascorbic Acid; EC 1.1.-/Sugar Alcohol Dehydrogenases; EC Oxidase

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