| Liver L-gulonolactone oxidase activity and tissue ascorbic acid concentrations in nursing pigs and the effect of various weaning ages. | |
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MedLine Citation:
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PMID: 11435521 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In Experiment 1, we evaluated liver L-gulono-gamma-lactone oxidase (GLO) activity and tissue concentration of ascorbic acid in young pigs from birth to weaning (14 d) and through a 28-d postweaning period; in Experiment 2, we evaluated the effect of three weaning ages on these measurements. Sow colostrum and milk collected in both experiments demonstrated a linear decline (P < 0.01) in ascorbic acid concentration as lactation progressed. In Experiment 1, three pigs were killed at 0, 3, 7, 14, 21, 28, 35 and 42 d of age for determining liver GLO activity and serum and tissue ascorbic acid. Liver GLO activity decreased by 80% from 0 to 3 d of age and remained low until d 14 (weaning). After weaning, liver GLO activity increased linearly (P < 0.01). Tissue ascorbic acid concentrations decreased during the nursing period and again after weaning, but then increased to 42 d of age (P < 0.01). In Experiment 2, pigs were weaned at 10, 17 or 24 d of age. Three pigs from each group were killed at weaning and at each week postweaning until 38 d of age. Liver GLO activity was low during the nursing period but increased linearly (P < 0.01) for each group during the subsequent postweaning period. Pig serum and tissue ascorbic acid concentrations increased postweaning in each group. These results suggest that a factor in sow's milk, possibly ascorbic acid, suppressed liver GLO activity of nursing pigs but upon weaning, liver GLO activity of pigs increased in a linear manner (P < 0.01). |
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Authors:
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S Ching; D C Mahan; K Dabrowski |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: The Journal of nutrition Volume: 131 ISSN: 0022-3166 ISO Abbreviation: J. Nutr. Publication Date: 2001 Jul |
Date Detail:
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Created Date: 2001-07-03 Completed Date: 2001-08-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0404243 Medline TA: J Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 2002-6 Citation Subset: IM |
Affiliation:
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Department of Animal Sciences, The Ohio State University and The Ohio Agricultural Research and Development Center, Columbus, OH 43210-1094, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Animal Feed Animals Animals, Newborn Animals, Suckling / metabolism* Ascorbic Acid / analysis, metabolism* Colostrum / chemistry Female L-Gulonolactone Oxidase Lactation Liver / enzymology* Milk / chemistry Nutritional Status Sugar Alcohol Dehydrogenases / metabolism* Swine / metabolism* Weaning |
| Chemical | |
Reg. No./Substance:
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50-81-7/Ascorbic Acid; EC 1.1.-/Sugar Alcohol Dehydrogenases; EC 1.1.3.8/L-Gulonolactone Oxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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