| Liver AMP-activated protein kinase and acetyl-CoA carboxylase during and after exercise. | |
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MedLine Citation:
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PMID: 9931206 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Exercise induces a decline in liver malonyl-CoA, an inhibitor of carnitine palmitoyltransferase-1. The purpose of these experiments was to determine whether this decrease in malonyl-CoA is accompanied by an activation of AMP-activated protein kinase (AMPK) and inactivation of acetyl-CoA carboxylase (ACC). Rats were killed at rest, after 10 min of running at 32 m/min up a 15% grade or at 0, 15, or 60 min postexercise after 120 min of running at 16 m/min. There was no significant difference in AMPK and ACC activities after 120 min of exercise, although a trend toward a decrease in ACC and an increase in AMPK was noted 15 min postexercise. After 10 min at 32 m/min, however, maximal ACC activity decreased from 487 +/- 27 to 280 +/- 39 nmol. g-1. min-1, and the activation constant for citrate activation of ACC increased from 5.9 to 12.5 mM. AMPK activity increased from a resting value of 4.7 +/- 0.4 to 9.8 +/- 2.0 pmol. mg-1. min-1 after exercise. These data provide indirect evidence of phosphorylation and inactivation of liver ACC during heavy exercise. In contrast, the decrease in malonyl-CoA during long-term, low-intensity exercise may occur by mechanisms other than phosphorylation of ACC. |
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Authors:
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C L Carlson; W W Winder |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 86 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 1999 Feb |
Date Detail:
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Created Date: 1999-03-22 Completed Date: 1999-03-22 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 669-74 Citation Subset: IM |
Affiliation:
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Department of Zoology, Brigham Young University, Provo, Utah 84602, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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AMP-Activated Protein Kinases Acetyl-CoA Carboxylase / metabolism* Animals Blood Glucose / metabolism Citrates / metabolism Glucagon / blood Hormones / blood Liver / enzymology*, metabolism Liver Glycogen / metabolism Multienzyme Complexes / metabolism* Physical Exertion* Protein Kinases / metabolism* Protein-Serine-Threonine Kinases* Rats Rats, Sprague-Dawley |
| Grant Support | |
ID/Acronym/Agency:
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AR-41438/AR/NIAMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Citrates; 0/Hormones; 0/Liver Glycogen; 0/Multienzyme Complexes; 9007-92-5/Glucagon; EC 2.7.-/Protein Kinases; EC 2.7.11.1/AMP-Activated Protein Kinases; EC 2.7.11.1/Protein-Serine-Threonine Kinases; EC 6.4.1.2/Acetyl-CoA Carboxylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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