| Live imaging of neuronal connections by magnetic resonance: Robust transport in the hippocampal-septal memory circuit in a mouse model of Down syndrome. | |
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MedLine Citation:
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PMID: 17566763 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Connections from hippocampus to septal nuclei have been implicated in memory loss and the cognitive impairment in Down syndrome (DS). We trace these connections in living mice by Mn(2+) enhanced 3D MRI and compare normal with a trisomic mouse model of DS, Ts65Dn. After injection of 4 nl of 200 mM Mn(2+) into the right hippocampus, Mn(2+) enhanced circuitry was imaged at 0.5, 6, and 24 h in each of 13 different mice by high resolution MRI to detect dynamic changes in signal over time. The pattern of Mn(2+) enhanced signal in vivo correlated with the histologic pattern in fixed brains of co-injected 3kD rhodamine-dextran-amine, a classic tracer. Statistical parametric mapping comparing intensity changes between different time points revealed that the dynamics of Mn(2+) transport in this pathway were surprisingly more robust in DS mice than in littermate controls, with statistically significant intensity changes in DS appearing at earlier time points along expected pathways. This supports reciprocal alterations of transport in the hippocampal-forebrain circuit as being implicated in DS and argues against a general failure of transport. This is the first examination of in vivo transport dynamics in this pathway and the first report of elevated transport in DS. |
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Authors:
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Elaine L Bearer; Xiaowei Zhang; Russell E Jacobs |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2007-05-18 |
Journal Detail:
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Title: NeuroImage Volume: 37 ISSN: 1053-8119 ISO Abbreviation: Neuroimage Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-07-30 Completed Date: 2007-10-12 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 9215515 Medline TA: Neuroimage Country: United States |
Other Details:
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Languages: eng Pagination: 230-42 Citation Subset: IM |
Affiliation:
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Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02912, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Axonal Transport / physiology* Brain Mapping Cholinergic Fibers / pathology Disease Models, Animal* Dominance, Cerebral Down Syndrome / genetics, pathology* Hippocampus / pathology* Image Enhancement / methods* Image Processing, Computer-Assisted / methods* Magnetic Resonance Imaging / methods* Male Mental Recall / physiology* Mice Mice, Neurologic Mutants Nerve Net / pathology* Prosencephalon / pathology* Septum Pellucidum / pathology* |
| Grant Support | |
ID/Acronym/Agency:
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GM47368/GM/NIGMS NIH HHS; NS046810/NS/NINDS NIH HHS; R01 DA018184-02/DA/NIDA NIH HHS; R01 GM047368-09/GM/NIGMS NIH HHS; R01 NS046810-04/NS/NINDS NIH HHS; R01DA018184/DA/NIDA NIH HHS; U24 RR021760/RR/NCRR NIH HHS; U24 RR021760-03/RR/NCRR NIH HHS |
| Comments/Corrections | |
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