Document Detail

Live cell imaging reveals plant aurora kinase has dual roles during mitosis.
MedLine Citation:
PMID:  18593743     Owner:  NLM     Status:  MEDLINE    
The proper segregation of chromosomes during mitosis is required for accurate distribution of genetic information by two daughter cells. Here, we used live cell imaging of microtubules and kinetochores after treatment with an Aurora kinase inhibitor, hesperadin, in tobacco BY-2 cells to analyze the function of plant Aurora kinase during mitosis. Hesperadin treatment induced the delay of CenH3 alignment on the spindle equator. Furthermore, two types of dynamics of lagging CenH3s were observed during chromosome segregation. The findings indicate that the plant Aurora kinase has dual roles; correction of aberrant kinetochore-microtubule attachment and dissociation of cohesin during chromosome alignment and segregation.
Daisuke Kurihara; Sachihiro Matsunaga; Susumu Uchiyama; Kiichi Fukui
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-07-01
Journal Detail:
Title:  Plant & cell physiology     Volume:  49     ISSN:  1471-9053     ISO Abbreviation:  Plant Cell Physiol.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-07     Completed Date:  2008-10-31     Revised Date:  2011-07-11    
Medline Journal Info:
Nlm Unique ID:  9430925     Medline TA:  Plant Cell Physiol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1256-61     Citation Subset:  IM    
Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871 Japan.
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MeSH Terms
Cell Line
Indoles / pharmacology
Mitosis / drug effects*,  physiology*
Protein-Serine-Threonine Kinases / antagonists & inhibitors,  metabolism*
Sulfonamides / pharmacology
Tobacco / cytology*
Reg. No./Substance:
0/Indoles; 0/Sulfonamides; 0/hesperadin; EC Kinases; EC kinase

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