Document Detail

Live birth sex ratios are not influenced by blastocyst-stage embryo transfer.
MedLine Citation:
PMID:  18774561     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To analyze the sex ratio of infants born after blastocyst-stage transfer of embryos with normal preimplantation FISH genetic screening. DESIGN: Retrospective cohort analysis. SETTING: Large academic assisted reproductive technology center. PATIENT(S): Two hundred twenty-eight patients undergoing fresh IVF cycle with blastocyst transfer. INTERVENTION(S): Preimplantation genetic screening for sex complement. MAIN OUTCOME MEASURE(S): Sex ratio in liveborn infants following blastocyst transfer. RESULT(S): One thousand thirteen embryos were normal by preimplantation genetic screening of chromosomes 13, 15, 16, 17, 18, 21, 22, X, and Y. Four hundred ninety-eight normal embryos were transferred to 228 patients with an overall live birth rate of 41.7%. Transferred blastocysts were selected based upon morphologic assessment. When controlling for the sex of the blastocyst embryo, there was no difference in the male-to-female delivery rate per embryo transferred (27.3% vs. 21.4%) (relative risk =1.28, confidence interval 0.93-1.74). Of the live births 51.7% were male and 48.3% were female (P=.61). Subanalysis revealed no difference in male-to-female delivery rates in groups with a 1:1 ratio of male:female embryos transferred, a non 1:1 ratio transferred, or single-sex transfers. CONCLUSION(S): Blastocyst-stage embryo transfer does not influence the live birth sex ratio of embryos with normal preimplantation FISH genetic screening.
John M Csokmay; Micah J Hill; Frank V Cioppettini; Kathleen A Miller; Richard T Scott; John L Frattarelli
Publication Detail:
Type:  Journal Article     Date:  2008-09-06
Journal Detail:
Title:  Fertility and sterility     Volume:  92     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-31     Completed Date:  2009-09-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  913-7     Citation Subset:  IM    
National Institutes of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.
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MeSH Terms
Blastocyst / cytology*
Cohort Studies
Embryo Transfer / methods*
Fertilization in Vitro / methods
Genetic Screening
Live Birth*
Pregnancy Outcome
Pregnancy Rate
Retrospective Studies
Sex Ratio*

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