Document Detail

Live birth from a frozen-thawed pronuclear stage embryo almost 20 years after its cryopreservation.
MedLine Citation:
PMID:  20887984     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: To report a live birth after transfer of cryopreserved pronuclear embryos in cryostorage for almost 20 years.
DESIGN: Case report.
SETTING: Academic IVF center.
PATIENT(S): A 42-year-old female patient with low ovarian reserve receiving donated embryos. These embryos were the result of an anonymous donation from an infertile couple who had conceived during her IVF treatment.
INTERVENTION(S): Cryopreservation (slow-freeze method) and thawing of pronuclear stage embryos, and ultrasound-guided uterine ET.
RESULT(S): Five pronuclear embryos were thawed; two embryos survived, cleaved, and were transferred on day 2. A singleton term pregnancy was achieved with the delivery of a healthy boy.
CONCLUSION(S): A healthy live birth was documented after uterine transfer of pronuclear stage cryopreserved (slow freeze)-thawed embryos that were in storage for 19 years and 7 months. To our knowledge this case represents the "oldest" cryopreserved human embryos resulting in a live birth to date.
Donna Dowling-Lacey; Jacob F Mayer; Estella Jones; Silvina Bocca; Laurel Stadtmauer; Sergio Oehninger
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Fertility and sterility     Volume:  95     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1120.e1-3     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
The Jones Institute for Reproductive Medicine, Eastern Virginia Medical School, Norfolk, Virginia.
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