| Live birth after anonymous donation of twice-cryopreserved embryos that had been stored in liquid nitrogen for a cumulative storage time of approximately 13.5 years. | |
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MedLine Citation:
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PMID: 20542503 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To report a live birth after transfer of anonymously donated, twice-cryopreserved embryos that had been stored in liquid nitrogen for approximately 13.5 years. DESIGN: Case report. SETTING: A private assisted reproduction center. PATIENT(S): A 44-year-old recipient of donated cryopreserved embryos. INTERVENTION(S): Anonymous donation of cryopreserved blastocysts for procreation. MAIN OUTCOME MEASURE(S): Live birth after thawing and replacement of re-cryopreserved blastocysts. RESULT(S): Fourteen pronuclear-stage embryos and four cleavage-stage embryos were cryopreserved during a primary IVF cycle. In two separate cycles, one cycle for the primary patient and a subsequent cycle for the first embryo donor recipient, the 18 embryos were thawed and grown to the blastocyst stage for transfer. Supernumerary blastocysts (n = 5) not replaced at either of these two thaw cycles were re-cryopreserved and subsequently donated to another embryo donor recipient. Five blastocysts survived the thaw and three were transferred, resulting in a live birth. The embryos were cryopreserved for a cumulative storage time of approximately 4,909 days (13.4 years). CONCLUSION(S): The longevity (viability) of cryopreserved embryos maintained in liquid nitrogen remains to be determined; cryopreserved embryo donation for procreation should not be overlooked, regardless of the length of time that embryos remain in cryostorage. |
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Authors:
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Michael L Reed; Amanda Hamic; Charles L Caperton; Douglas J Thompson |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2010-06-09 |
Journal Detail:
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Title: Fertility and sterility Volume: 94 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-26 Completed Date: 2011-01-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 2771.e1-3 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Center for Reproductive Medicine of New Mexico, Albuquerque, New Mexico 87106, USA. mleroyreed@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anonyms and Pseudonyms Cryopreservation / methods* Embryo, Mammalian* Female Humans Infant, Newborn Live Birth* Male Nitrogen Oocyte Donation / methods* Pregnancy Time Factors |
| Chemical | |
Reg. No./Substance:
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7727-37-9/Nitrogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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