Document Detail

Live birth after anonymous donation of twice-cryopreserved embryos that had been stored in liquid nitrogen for a cumulative storage time of approximately 13.5 years.
MedLine Citation:
PMID:  20542503     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To report a live birth after transfer of anonymously donated, twice-cryopreserved embryos that had been stored in liquid nitrogen for approximately 13.5 years.
DESIGN: Case report.
SETTING: A private assisted reproduction center.
PATIENT(S): A 44-year-old recipient of donated cryopreserved embryos.
INTERVENTION(S): Anonymous donation of cryopreserved blastocysts for procreation.
MAIN OUTCOME MEASURE(S): Live birth after thawing and replacement of re-cryopreserved blastocysts.
RESULT(S): Fourteen pronuclear-stage embryos and four cleavage-stage embryos were cryopreserved during a primary IVF cycle. In two separate cycles, one cycle for the primary patient and a subsequent cycle for the first embryo donor recipient, the 18 embryos were thawed and grown to the blastocyst stage for transfer. Supernumerary blastocysts (n = 5) not replaced at either of these two thaw cycles were re-cryopreserved and subsequently donated to another embryo donor recipient. Five blastocysts survived the thaw and three were transferred, resulting in a live birth. The embryos were cryopreserved for a cumulative storage time of approximately 4,909 days (13.4 years).
CONCLUSION(S): The longevity (viability) of cryopreserved embryos maintained in liquid nitrogen remains to be determined; cryopreserved embryo donation for procreation should not be overlooked, regardless of the length of time that embryos remain in cryostorage.
Michael L Reed; Amanda Hamic; Charles L Caperton; Douglas J Thompson
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2010-06-09
Journal Detail:
Title:  Fertility and sterility     Volume:  94     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-26     Completed Date:  2011-01-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2771.e1-3     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Center for Reproductive Medicine of New Mexico, Albuquerque, New Mexico 87106, USA.
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MeSH Terms
Anonyms and Pseudonyms
Cryopreservation / methods*
Embryo, Mammalian*
Infant, Newborn
Live Birth*
Oocyte Donation / methods*
Time Factors
Reg. No./Substance:

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