Document Detail

Live Salmonella enterica serovar Typhimurium (S. Typhimurium) elicit dendritic cell responses that differ from those induced by killed S. Typhimurium.
MedLine Citation:
PMID:  15010228     Owner:  NLM     Status:  MEDLINE    
The immune response of bovine monocytes-derived dendritic cells (DC) exposed to either live or killed Salmonella enterica serovar Typhimurium was compared. Both live and killed bacteria induced changes in morphology with distinctive formation of processes and up-regulation of the ability of DC to stimulate allogeneic T-cell proliferation. Also, both live and killed bacteria up-regulated the expression of MHC-I, MHC-II and CD80. However, live bacteria induced greater up-regulation of the expression of CD40 and CD86 than killed bacteria. Live bacteria also induced greater up-regulation of transcription for IL-6, IL-12 and GM-CSF than killed bacteria as measured by quantitative RT-PCR. These data suggest that blood-monocyte-derived DC may follow distinct maturation pathways following exposure to live or killed bacteria. These differences are likely to have consequences for the priming of the adaptive immune responses.
Mari Norimatsu; Victoria Chance; Gordon Dougan; Christopher J Howard; Bernardo Villarreal-Ramos
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Veterinary immunology and immunopathology     Volume:  98     ISSN:  0165-2427     ISO Abbreviation:  Vet. Immunol. Immunopathol.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-03-10     Completed Date:  2004-05-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8002006     Medline TA:  Vet Immunol Immunopathol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  193-201     Citation Subset:  IM    
Institute for Animal Health, Compton, Newbury, Berkshire RG20 7NN, UK.
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MeSH Terms
Antigens, CD / genetics,  immunology,  metabolism
Bacterial Vaccines / immunology*
Cattle / immunology*
Cell Differentiation / immunology
Dendritic Cells / cytology,  immunology*
Histocompatibility Antigens Class I / immunology,  metabolism
Histocompatibility Antigens Class II / immunology,  metabolism
Nitric Oxide Synthase / chemistry,  genetics,  immunology
Nitric Oxide Synthase Type II
RNA, Messenger / chemistry,  genetics
Reverse Transcriptase Polymerase Chain Reaction / veterinary
Salmonella Infections, Animal / immunology*,  microbiology
Salmonella typhimurium / immunology*
Vaccines, Attenuated / immunology
Vaccines, Inactivated / immunology
Reg. No./Substance:
0/Antigens, CD; 0/Bacterial Vaccines; 0/Histocompatibility Antigens Class I; 0/Histocompatibility Antigens Class II; 0/RNA, Messenger; 0/Vaccines, Attenuated; 0/Vaccines, Inactivated; EC Oxide Synthase; EC Oxide Synthase Type II

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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