| Live Legionella pneumophila induces MUC5AC production by airway epithelial cells independently of intracellular invasion. | |
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MedLine Citation:
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PMID: 22260247 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The airway epithelium is the initial barrier against airborne pathogens, and it plays many roles in host airway defense. Legionella pneumophila is an intracellular pathogen that causes rapidly advancing pneumonia and is sometimes life-threatening. Here, we evaluated the role of the airway epithelial cells in the defense against L. pneumophila by examining mucus production in vitro. The production of MUC5AC, a major mucin protein, was not induced by formalin- or ultraviolet-killed L. pneumophila, but it was induced by live L. pneumophila. Similarly, nuclear factor-kappaB (NF-κB) was activated only by live L. pneumophila. Inhibitors of ERK and JNK, but not p38, dose-dependently inhibited the induction of MUC5AC by live L. pneumophila. Inhibition of intracellular invasion by cytochalasin D did not affect MUC5AC production. Taken together, the results suggest that live L. pneumophila induces MUC5AC production via the ERK-JNK and NF-κB pathways without internalization of bacteria and that the airway epithelium produces mucin as part of the immune response against L. pneumophila. |
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Authors:
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Yoshitomo Morinaga; Katsunori Yanagihara; Nobuko Araki; Yohei Migiyama; Kentaro Nagaoka; Yosuke Harada; Koichi Yamada; Hiroo Hasegawa; Tomoya Nishino; Koichi Izumikawa; Hiroshi Kakeya; Yoshihiro Yamamoto; Shigeru Kohno; Shimeru Kamihira |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-20 |
Journal Detail:
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Title: Canadian journal of microbiology Volume: - ISSN: 1480-3275 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372707 Medline TA: Can J Microbiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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a Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1, Sakamoto, Nagasaki, 852-8501, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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