| Little exercise, big effects: reversing aging and infection-induced memory deficits, and underlying processes. | |
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MedLine Citation:
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PMID: 21832188 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have previously found that healthy aged rats are more likely to suffer profound memory impairments following a severe bacterial infection than are younger adult rats. Such a peripheral challenge is capable of producing a neuroinflammatory response, and in the aged brain this response is exaggerated and prolonged. Normal aging primes, or sensitizes, microglia, and this appears to be the source of this amplified inflammatory response. Among the outcomes of this exaggerated neuroinflammatory response are impairments in synaptic plasticity and reductions of brain-derived neurotrophic factor (BDNF), both of which have been associated with cognitive impairments. Since it has been shown that physical exercise increases BDNF mRNA in the hippocampus, the present study examined voluntary exercise in 24-month-old F344×BN rats as a neuroprotective therapeutic in our bacterial infection model. Although aged rats ran only an average of 0.7 km per week, this small amount of exercise was sufficient to completely reverse infection-induced impairments in hippocampus-dependent long-term memory compared with sedentary animals. Strikingly, exercise prevented the infection-induced exaggerated neuroinflammatory response and the blunted BDNF mRNA induction seen in the hippocampus of sedentary rats. Moreover, voluntary exercise abrogated age-related microglial sensitization, suggesting a possible mechanism for exercise-induced neuroprotection in aging. |
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Authors:
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Ruth M Barrientos; Matthew G Frank; Nicole Y Crysdale; Timothy R Chapman; Jared T Ahrendsen; Heidi E W Day; Serge Campeau; Linda R Watkins; Susan L Patterson; Steven F Maier |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 31 ISSN: 1529-2401 ISO Abbreviation: J. Neurosci. Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-08-11 Completed Date: 2011-10-04 Revised Date: 2012-02-13 |
Medline Journal Info:
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Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 11578-86 Citation Subset: IM |
Affiliation:
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Department of Psychology and Neuroscience, University of Colorado at Boulder, Boulder, Colorado 80309, USA. ruth.barrientos@colorado.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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physiology* Animals Escherichia coli Infections / complications, physiopathology, prevention & control* Exercise Test / methods Hippocampus / microbiology, physiology Male Memory Disorders / microbiology, physiopathology, prevention & control* Physical Conditioning, Animal / methods* Rats Rats, Inbred BN Rats, Inbred F344 |
| Grant Support | |
ID/Acronym/Agency:
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R01 AG028271-05/AG/NIA NIH HHS; R01AG02827/AG/NIA NIH HHS; R21AG031467/AG/NIA NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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