Document Detail


Little evidence of association between severity of trigonocephaly and cognitive development in infants with single-suture metopic synostosis.
MedLine Citation:
PMID:  20644427     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To measure severity of trigonocephaly among infants with single-suture metopic craniosynostosis by using a novel shape descriptor, the trigonocephaly severity index (TSI), and to evaluate whether degree of trigonocephaly correlates with their neurodevelopmental test scores.
METHODS: We conducted a multicenter cross-sectional and longitudinal study, identifying and recruiting 65 infants with metopic synostosis before their corrective surgery. We obtained computed tomography images for 49 infants and measured the presurgical TSI, a 3-dimensional outline-based cranial shape descriptor. We evaluated neurodevelopment by administering the Bayley Scales of Infant Development, Second Edition, and the Preschool Language Scale, Third Edition, before surgery and at 18 and 36 months of age. We fit linear regression models to estimate associations between test scores and TSI values adjusted for age at testing and race/ethnicity. We fit logistic regression models to estimate whether the odds of developmental delay were increased among children with more severe trigonocephaly.
RESULTS: We observed little adjusted association between neurodevelopmental test scores and TSI values, and no associations that persisted at 3 years. Trigonocephaly was less severe among children referred at older ages.
CONCLUSION: We observed little evidence of an association between the severity of trigonocephaly among metopic synostosis patients and their neurodevelopmental test scores. Detecting such a relationship with precision may require larger sample sizes or alternative phenotypic quantifiers. Until studies are conducted to explore these possibilities, it appears that although associated with the presence of metopic synostosis, the risk of developmental delays in young children is unrelated to further variation in trigonocephalic shape.
Authors:
Jacqueline R Starr; H Jill Lin; Salvador Ruiz-Correa; Michael L Cunningham; Richard G Ellenbogen; Brent R Collett; Kathleen A Kapp-Simon; Matthew L Speltz
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurosurgery     Volume:  67     ISSN:  1524-4040     ISO Abbreviation:  Neurosurgery     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-20     Completed Date:  2011-01-21     Revised Date:  2012-09-26    
Medline Journal Info:
Nlm Unique ID:  7802914     Medline TA:  Neurosurgery     Country:  United States    
Other Details:
Languages:  eng     Pagination:  408-15; discussion 415-6     Citation Subset:  IM    
Affiliation:
Departments of Pediatrics and Epidemiology, University of Washington, Children's Craniofacial Center, Seattle Children's Hospital, Seattle, Washington, USA.
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MeSH Terms
Descriptor/Qualifier:
Child Behavior
Child Development
Child, Preschool
Cognition Disorders / etiology*
Craniosynostoses / pathology*,  psychology*,  surgery
Cross-Sectional Studies
Female
Follow-Up Studies
Humans
Infant
Language Development
Linear Models
Longitudinal Studies
Magnetic Resonance Imaging
Male
Neuropsychological Tests
Neurosurgical Procedures
Prospective Studies
Tomography, X-Ray Computed
Grant Support
ID/Acronym/Agency:
R01 DE013813/DE/NIDCR NIH HHS; R01-DE 13813/DE/NIDCR NIH HHS
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